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人乳中特异性IgA抗体的波动

Fluctuation of specific IgA antibodies in human milk.

作者信息

Cruz J R, Arévalo C

出版信息

Acta Paediatr Scand. 1985 Nov;74(6):897-903. doi: 10.1111/j.1651-2227.1985.tb10055.x.

DOI:10.1111/j.1651-2227.1985.tb10055.x
PMID:3004100
Abstract

The concentration of secretory IgA and the levels of IgA specific antibodies against Escherichia coli labile-toxin, Shigella flexneri 6, and rotaviruses were determined in milk samples obtained serially from women during the first 16 weeks postpartum. The mean concentration of secretory IgA followed the expected pattern; the levels of specific antibodies fluctuated in an unpredictable manner and independently of milk secretory IgA content, becoming undetectable in many instances. Under some circumstances, continued breast-feeding may not guarantee continued intake of antibodies against intestinal pathogens by the breast-fed infant.

摘要

测定了产后16周内从女性身上连续采集的乳汁样本中分泌型IgA的浓度以及针对大肠杆菌不耐热毒素、福氏志贺菌6型和轮状病毒的IgA特异性抗体水平。分泌型IgA的平均浓度符合预期模式;特异性抗体水平以不可预测的方式波动,且与乳汁分泌型IgA含量无关,在许多情况下无法检测到。在某些情况下,持续母乳喂养可能无法保证母乳喂养的婴儿持续摄入针对肠道病原体的抗体。

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Fluctuation of specific IgA antibodies in human milk.人乳中特异性IgA抗体的波动
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引用本文的文献

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Detection and characterization of antibodies specific to food antigens (gliadin, ovalbumin and beta-lactoglobulin) in human serum, saliva, colostrum and milk.检测和鉴定人血清、唾液、初乳和乳汁中针对食物抗原(麦醇溶蛋白、卵清蛋白和β-乳球蛋白)的特异性抗体。
Clin Exp Immunol. 1998 Jun;112(3):453-8. doi: 10.1046/j.1365-2249.1998.00587.x.
2
IgA antibodies in human milk: epidemiological markers of previous infections?人乳中的IgA抗体:既往感染的流行病学标志物?
Arch Dis Child Fetal Neonatal Ed. 1994 Nov;71(3):F192-7. doi: 10.1136/fn.71.3.f192.
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Presence of secretory IgA antibodies to an enteric bacterial pathogen in human milk and saliva.
人乳和唾液中存在针对肠道细菌病原体的分泌型IgA抗体。
Arch Dis Child Fetal Neonatal Ed. 1995 Mar;72(2):F102-6. doi: 10.1136/fn.72.2.f102.