1 CERVO Brain Research Centre, Quebec, Canada.
2 École de psychologie, Université Laval, Quebec, Canada.
Am J Alzheimers Dis Other Demen. 2018 Nov;33(7):401-414. doi: 10.1177/1533317518788151. Epub 2018 Jul 24.
BACKGROUND/RATIONALE: This systematic review aims to evaluate the efficacy of the nonpharmacological interventions reducing burden, psychological symptoms, and improving quality of life of caregivers of individuals with mild cognitive impairment (MCI).
Databases reviewed included Medline, Cochrane Library, Embase, PsycNet, AgeLine, and ProQuest Dissertations and Theses. Studies using an experimental/quasi-experimental design including nonpharmacological intervention were included. Four studies were included, and no meta-analysis was conducted.
Calendar training and note-taking (cognitive intervention) significantly decreased caregiver's depressive symptoms and prevented worsening of subjective burden 6 months posttreatment. Daily engagement of meaningful activity combined with problem-solving therapy and educational material reduced depressive symptoms 3 months posttreatment. Moreover, educational intervention and social conversation phone calls decreased caregiver burden 3 months posttreatment.
Studies suggest that nonpharmacological interventions can support caregivers of older adults with MCI, but the few published articles present some bias and are inconclusive. Randomized-controlled trials targeting specifically caregivers are needed to determine the most efficient type of interventions for those individuals.
背景/理由：本系统评价旨在评估非药物干预措施减轻轻度认知障碍（MCI）患者照顾者负担、心理症状和提高生活质量的疗效。
检索的数据库包括 Medline、Cochrane 图书馆、Embase、PsycNet、AgeLine 和 ProQuest 学位论文和论文。纳入使用包括非药物干预在内的实验/准实验设计的研究。共纳入 4 项研究，但未进行荟萃分析。
日历训练和记笔记（认知干预）可显著降低照顾者的抑郁症状，并在治疗后 6 个月预防主观负担恶化。每天进行有意义的活动并结合解决问题的疗法和教育材料可在治疗后 3 个月降低抑郁症状。此外，教育干预和社交电话交谈可在治疗后 3 个月降低照顾者负担。
研究表明，非药物干预可以为 MCI 老年患者的照顾者提供支持，但已发表的少数几篇文章存在一些偏倚，结论尚不确定。需要针对特定照顾者的随机对照试验来确定针对这些个体最有效的干预类型。
