Arthritis Care Res (Hoboken). 2014 May;66(5):757-64. doi: 10.1002/acr.22227.
To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well-characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.
Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.
Primary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age- and sex-matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.
Primary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age- and sex-matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.
使用既定定义，在一大群临床特征明确的原发性干燥综合征（SS）患者中确定传统心血管危险因素的流行情况，并将其与健康对照进行比较。
使用标准化表格前瞻性收集原发性 SS 患者和对照者的心血管危险因素数据。根据既定定义定义心血管危险因素。确定原发性 SS 组中心血管危险因素的患病率，并与对照组进行比较。
原发性 SS 患者的高血压（28-50%对 15.5-25.6%；P<0.01）和高三酰甘油血症（21%对 9.5%；P=0.002）的患病率高于年龄和性别匹配的健康对照者。此外，根据最佳实践，预期需要接受抗高血压治疗的高血压患者中，有相当大比例（56%）未接受治疗。
原发性 SS 患者发生高血压和高三酰甘油血症的风险是年龄和性别匹配的健康对照者的两倍以上。此外，原发性 SS 中高血压的诊断不足且治疗不充分。
