Hilfenhaus J, Weidmann E
Arzneimittelforschung. 1985;35(11):1617-9.
Fibrin glue has become an indispensable tool in salvaging operations of the parenchymatous organs of the abdomen, in vascular and ophthalmic plastic surgery as well as neurosurgery. Currently available glues contain clotting factors from human plasma and thus carry the potential risk of transmitting viral infections like hepatitis or acquired immunodeficiency syndrome (AIDS). Combined efforts in selection of plasma donations as well as pasteurization of the human plasma products allow the manufacturing of a product (Beriplast) with virtually no risk of transmission of viral infections as demonstrated by in vivo and in vitro experiments with a variety of human pathogenic viruses. No changes in activity or antigenicity of the clotting factors by the pasteurization procedure have been encountered.
纤维蛋白胶已成为腹部实质器官挽救手术、血管及眼科整形手术以及神经外科手术中不可或缺的工具。目前市面上的胶水含有来自人血浆的凝血因子，因此存在传播病毒性感染（如肝炎或获得性免疫缺陷综合征（艾滋病））的潜在风险。在选择血浆捐献以及对人血浆制品进行巴氏消毒方面的共同努力，使得生产出一种产品（百瑞普莱士）成为可能，各种人类致病病毒的体内和体外实验表明，该产品几乎不存在传播病毒性感染的风险。通过巴氏消毒程序，未发现凝血因子的活性或抗原性发生变化。
