Moshkov K A, Burmistrov S O, Usatenko M S, Grinenko A Ia, Petrov V P
Farmakol Toksikol. 1986 Jan-Feb;49(1):92-6.
The concentrations of the enzymatically active and immunoreactive ceruloplasmin (CP) were determined in the blood serum of healthy men by means of the spectrophotometric and immuno-electro-photometric methods. Part of the total (immunoreactive) CP (15%), circulated in the blood channel in an enzymatically inactive state. The increase of the time of suffering from chronic alcoholism from 1 to 29 years leads to the growth of the concentrations of CP possessing enzymatic activity and of immunoreactive CP. The share of the enzymatically inactive protein remains practically constant. During acute alcohol intoxication there is a temporal drop of the C1 share in enzymatically active state with a constant concentration of the total protein in the blood serum.
采用分光光度法和免疫电光光度法测定了健康男性血清中酶活性铜蓝蛋白（CP）和免疫反应性铜蓝蛋白的浓度。总（免疫反应性）CP的一部分（15%）以酶无活性状态在血液循环中流通。慢性酒精中毒时长从1年增加到29年，导致具有酶活性的CP和免疫反应性CP浓度升高。酶无活性蛋白的比例实际上保持不变。急性酒精中毒期间，血清中处于酶活性状态的C1比例暂时下降，而血清中总蛋白浓度保持不变。
