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Restriction fragment length polymorphism of the insulin gene region in Japanese diabetic and non-diabetic subjects.

作者信息

Awata T, Shibasaki Y, Hirai H, Okabe T, Kanazawa Y, Takaku F

出版信息

Diabetologia. 1985 Dec;28(12):911-3. doi: 10.1007/BF00703135.

DOI:10.1007/BF00703135
PMID:3005097
Abstract

A polymorphic locus flanking the 5' end of the insulin gene was studied in 154 unrelated Japanese diabetic and nondiabetic subjects. A predominance of the small allele was found with the following frequency: of 64 nondiabetic subjects, only 3 of 128 alleles were of the large class (2%); none of 78 alleles were of the large class in 39 Type 1 (insulin-dependent) diabetic subjects, and 4 of 102 alleles (4%) were of the large class in 51 Type 2 (non-insulin-dependent) diabetic subjects. The very low frequency of large allele may relate to the lower prevalence of atherosclerosis in Japanese. However, this possibility requires further examination.

摘要

相似文献

1
Restriction fragment length polymorphism of the insulin gene region in Japanese diabetic and non-diabetic subjects.
Diabetologia. 1985 Dec;28(12):911-3. doi: 10.1007/BF00703135.
2
High frequency of class 3 allele in the human insulin gene in Japanese type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes.在有糖尿病家族史的日本2型（非胰岛素依赖型）糖尿病患者中，人类胰岛素基因3类等位基因的高频率。
Diabetologia. 1986 Jun;29(6):402-4. doi: 10.1007/BF00903353.
3
Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects.日本非胰岛素依赖型糖尿病患者中人类胰岛素基因5'-侧翼插入的低频率
Diabetes Care. 1986 Jul-Aug;9(4):365-9. doi: 10.2337/diacare.9.4.365.
4
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus.人类胰岛素基因附近的一个多态性位点与胰岛素依赖型糖尿病相关。
Diabetes. 1984 Feb;33(2):176-83. doi: 10.2337/diab.33.2.176.
5
Polymorphic locus in the 5'-flanking region of human insulin gene and non-insulin-dependent diabetes mellitus.人类胰岛素基因5'侧翼区域的多态性位点与非胰岛素依赖型糖尿病
J Formos Med Assoc. 1990 Nov;89(11):965-8.
6
Polymorphism of insulin gene area in Japanese: relationship with insulin-dependent and non-insulin dependent diabetes.
Biomed Biochim Acta. 1988;47(4-5):317-21.
7
Low frequency of the large insertion in the human insulin gene in Japanese.日本人中人类胰岛素基因大插入的低频率。
Diabetes. 1986 Jan;35(1):115-8. doi: 10.2337/diab.35.1.115.
8
Restriction-fragment-length-polymorphisms close to the human insulin gene on chromosome 11 and their possible relation to diabetes mellitus in a GDR population.位于11号染色体上靠近人类胰岛素基因的限制性片段长度多态性及其与德意志民主共和国人群中糖尿病的可能关系。
Biomed Biochim Acta. 1988;47(4-5):311-5.
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Polymorphism of HLA and insulin gene is correlated to type I diabetes.人类白细胞抗原（HLA）和胰岛素基因的多态性与I型糖尿病相关。
Exp Clin Endocrinol. 1987 Aug;89(3):319-24. doi: 10.1055/s-0029-1210657.
10
Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review.
Diabetologia. 1985 Aug;28(8):556-64. doi: 10.1007/BF00281989.

引用本文的文献

1
In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.在芬兰，胰岛素基因区域编码的对胰岛素依赖型糖尿病的易感性，在HLA - DR相关风险较低时发挥最大作用。芬兰儿童糖尿病（DiMe）研究小组。
Diabetologia. 1995 Oct;38(10):1223-9. doi: 10.1007/BF00422373.
2
Lack of association of the insulin gene region with type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.日本人群中胰岛素基因区域与1型（胰岛素依赖型）糖尿病无关联。
Diabetologia. 1994 Feb;37(2):210-3. doi: 10.1007/s001250050095.
3
IDDM susceptibility associated with polymorphisms in the insulin gene region. A study of blacks, Caucasians and orientals.

本文引用的文献

1
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.人类胰岛素基因附近的高度多态性区域由简单串联重复序列组成。
Nature. 1982 Jan 7;295(5844):31-5. doi: 10.1038/295031a0.
2
Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.人类胰岛素基因5'侧翼区的多态性。与皮马印第安人非胰岛素依赖型糖尿病、血糖和胰岛素浓度以及糖尿病治疗的关系。
J Clin Invest. 1984 Dec;74(6):2129-35. doi: 10.1172/JCI111638.
3
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus.
与胰岛素基因区域多态性相关的胰岛素依赖型糖尿病易感性。一项针对黑人、白人和东方人的研究。
Diabetologia. 1994 Aug;37(8):745-9. doi: 10.1007/BF00404330.
4
High frequency of class 3 allele in the human insulin gene in Japanese type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes.在有糖尿病家族史的日本2型（非胰岛素依赖型）糖尿病患者中，人类胰岛素基因3类等位基因的高频率。
Diabetologia. 1986 Jun;29(6):402-4. doi: 10.1007/BF00903353.
5
Possible correlation between non-insulin dependent diabetes mellitus (NIDDM) and restriction fragment length polymorphism (RFLP) of the 5'-flanking region of insulin gene in Korean diabetic population.韩国糖尿病患者群体中非胰岛素依赖型糖尿病（NIDDM）与胰岛素基因5'-侧翼区限制性片段长度多态性（RFLP）之间的可能相关性。
Korean J Intern Med. 1987 Jul;2(2):140-6. doi: 10.3904/kjim.1987.2.2.140.
6
DNA polymorphism and the study of disease associations.DNA多态性与疾病关联研究
Hum Genet. 1988 Apr;78(4):299-312. doi: 10.1007/BF00291724.
7
Restriction fragment length polymorphism (RFLP) of the human insulin receptor gene in Japanese: its possible usefulness as a genetic marker.
Diabetologia. 1986 Sep;29(9):667-9. doi: 10.1007/BF00869268.
8
The genetic predisposition to fibrocalculous pancreatic diabetes.纤维钙化性胰腺糖尿病的遗传易感性。
Diabetologia. 1989 Jan;32(1):45-51. doi: 10.1007/BF00265403.
9
Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".人类基因组中串联重复DNA序列块的潜在遗传功能基于一种高度保守的“染色质折叠密码”。
Hum Genet. 1990 Mar;84(4):301-36. doi: 10.1007/BF00196228.
10
A genetic study of the human low-voltage electroencephalogram.人类低电压脑电图的遗传学研究。
Hum Genet. 1992 Sep-Oct;90(1-2):99-112. doi: 10.1007/BF00210751.
人类胰岛素基因附近的一个多态性位点与胰岛素依赖型糖尿病相关。
Diabetes. 1984 Feb;33(2):176-83. doi: 10.2337/diab.33.2.176.
4
Genetics of diabetes in Nauru: effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism.
Diabetologia. 1983 Jul;25(1):13-7. doi: 10.1007/BF00251889.
5
Restriction fragment length polymorphism of the insulin gene in diabetes mellitus.糖尿病中胰岛素基因的限制性片段长度多态性
Diabetes. 1982 Mar;31(3):275-7. doi: 10.2337/diab.31.3.275.
6
Polymorphism in the 5' flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes.人类胰岛素基因5'侧翼区的多态性：非胰岛素依赖型糖尿病的一种遗传标记。
N Engl J Med. 1983 Jan 13;308(2):65-71. doi: 10.1056/NEJM198301133080202.
7
Polymorphic DNA region adjacent to the 5' end of the human insulin gene.人类胰岛素基因5'端相邻的多态性DNA区域。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5759-63. doi: 10.1073/pnas.78.9.5759.
8
Polymorphism in the 5'-flanking region of the human insulin gene and its possible relation to type 2 diabetes.人类胰岛素基因5'侧翼区域的多态性及其与2型糖尿病的可能关系。
Science. 1981 Sep 4;213(4512):1117-20. doi: 10.1126/science.6267694.
9
DNA sequences flanking the insulin gene on chromosome 11 confer risk of atherosclerosis.
Lancet. 1984 Feb 4;1(8371):250-2. doi: 10.1016/s0140-6736(84)90126-0.
10
Possible association between DNA sequences flanking the insulin gene and atherosclerosis.胰岛素基因侧翼的DNA序列与动脉粥样硬化之间可能存在的关联。
Lancet. 1982 Dec 11;2(8311):1291-3. doi: 10.1016/s0140-6736(82)91505-7.