四季皆宜的酵母——巴斯德毕赤酵母是否适合未来的生物生产？
A yeast for all seasons - Is Pichia pastoris a suitable chassis organism for future bioproduction?
机构信息
Department of Biotechnology, BOKU University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria.
Austrian Centre of Industrial Biotechnology, Muthgasse 18, 1190 Vienna, Austria.
出版信息
FEMS Microbiol Lett. 2018 Sep 1;365(17). doi: 10.1093/femsle/fny181.
The methylotrophic yeast Pichia pastoris (Komagataella spp.) is well established as a host for recombinant protein production. Since a few years it has also been subject to metabolic engineering to produce a diversity of biochemicals. Based on these developments we discuss here why P. pastoris is a suitable future chassis organism for synthetic biology, and we provide a roadmap for a community effort towards this aim.
甲醇营养型酵母毕赤酵母（Komagataella spp.）已被广泛用作重组蛋白生产的宿主。近年来，它也已成为代谢工程的研究对象，用于生产多种生物化学物质。基于这些发展，我们在这里讨论了为什么毕赤酵母是合成生物学的合适未来底盘生物，并为实现这一目标的社区努力提供了路线图。
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