Tuero Gaspar, González Jesús, Sahuquillo Laura, Freixa Anna, Gomila Isabel, Elorza Miguel Ángel, Barceló Bernardino
Department of Intensive Care Medicine, Hospital Can Misses, Corona, s/n, 07800 Ibiza, Spain.
Clinical Analysis Department, Hospital Can Misses, Corona, s/n, 07800 Ibiza, Spain.
Forensic Sci Int. 2018 Sep;290:e9-e14. doi: 10.1016/j.forsciint.2018.07.007. Epub 2018 Jul 17.
To evaluate the clinical utility of glycolic acid (GA) determination in the diagnosis and prognosis of ethylene glycol (EG) intoxications.
Systematic review of serum and/or urine GA concentrations available in the literature in cases of EG poisoning. Present a clinical case in which the determination of the GA was decisive.
In total, 137 patients were included. Serum GA concentrations (but not EG) of patients who survive are different from those who die. The optimal cut-off of serum GA to predict mortality was 990.5mg/L (sensitivity 85.2%, specificity 54.3%) with an Odds Ratio of 6.838 (2.868-16.302). In our clinical case, serum EG was negative; however, urine GA was positive (1230.7mg/L).
In all suspected cases of EG poisoning, it is advisable to carry out the simultaneous analysis of EG and GA.
评估乙醇酸（GA）测定在乙二醇（EG）中毒诊断及预后判断中的临床应用价值。
系统回顾文献中有关EG中毒病例的血清和/或尿液GA浓度。呈现一例GA测定起决定性作用的临床病例。
共纳入137例患者。存活患者的血清GA浓度（而非EG浓度）与死亡患者不同。预测死亡率的血清GA最佳截断值为990.5mg/L（敏感性85.2%，特异性54.3%），优势比为6.838（2.868 - 16.302）。在我们的临床病例中，血清EG为阴性；然而，尿液GA为阳性（1230.7mg/L）。
在所有疑似EG中毒病例中，建议同时进行EG和GA分析。
