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本文引用的文献

1
Preconception exposure to dietary levels of genistein affects female reproductive outcomes.孕前摄入染料木黄酮的饮食水平会影响女性生殖结局。
Reprod Toxicol. 2017 Dec;74:174-180. doi: 10.1016/j.reprotox.2017.09.014. Epub 2017 Sep 29.
2
Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study.双酚A暴露、卵巢卵泡数量与女性性激素水平：CLARITY - BPA研究结果
Endocrinology. 2017 Jun 1;158(6):1727-1738. doi: 10.1210/en.2016-1887.
3
Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles.金雀异黄素暴露会抑制成年小鼠窦状卵泡的生长并改变其类固醇生成。
Toxicol Appl Pharmacol. 2016 Feb 15;293:53-62. doi: 10.1016/j.taap.2015.12.026. Epub 2016 Jan 12.
4
The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice.子宫内双酚A暴露对多代小鼠卵巢的影响。
Reprod Toxicol. 2016 Apr;60:39-52. doi: 10.1016/j.reprotox.2015.12.004. Epub 2015 Dec 30.
5
Acute Exposure to Di(2-Ethylhexyl) Phthalate in Adulthood Causes Adverse Reproductive Outcomes Later in Life and Accelerates Reproductive Aging in Female Mice.成年期急性暴露于邻苯二甲酸二（2-乙基己基）酯会导致后期出现不良生殖结局，并加速雌性小鼠的生殖衰老。
Toxicol Sci. 2016 Mar;150(1):97-108. doi: 10.1093/toxsci/kfv317. Epub 2015 Dec 16.
6
Understanding genistein in cancer: The "good" and the "bad" effects: A review.了解染料木黄酮在癌症中的作用：“好”与“坏”的影响：综述
Food Chem. 2016 Apr 1;196:589-600. doi: 10.1016/j.foodchem.2015.09.085. Epub 2015 Sep 26.
7
Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats.急性染料木黄酮处理通过增强年轻成年雌性大鼠的空间学习能力和损害反应学习能力来模拟雌二醇的作用。
Horm Behav. 2012 Sep;62(4):491-9. doi: 10.1016/j.yhbeh.2012.08.006. Epub 2012 Aug 27.
8
Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells.哺乳动物卵巢中的卵泡生长与闭锁：由颗粒细胞的存活和死亡调控
J Reprod Dev. 2012;58(1):44-50. doi: 10.1262/jrd.2011-012.
9
Reproductive consequences of developmental phytoestrogen exposure.发育性植物雌激素暴露的生殖后果。
Reproduction. 2012 Mar;143(3):247-60. doi: 10.1530/REP-11-0369. Epub 2012 Jan 5.
10
Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat.新生雌性大鼠接触染料木黄酮会对其下丘脑促性腺激素释放激素信号通路的发育和青春期前卵巢发育产生不良影响。
Reprod Toxicol. 2011 Apr;31(3):280-9. doi: 10.1016/j.reprotox.2010.10.002. Epub 2010 Oct 15.

日粮中染料木黄酮水平对卵巢卵泡数量和基因表达的影响。

The effects of dietary levels of genistein on ovarian follicle number and gene expression.

机构信息

Neuroscience Program, University of Illinois, 405 N Mathews Ave, Urbana, IL, 61801, United States.

Department of Comparative Biosciences College of Veterinary Medicine, University of Illinois 2001 S. Lincoln Ave, Urbana, IL, 61802, United States.

出版信息

Reprod Toxicol. 2018 Oct;81:132-139. doi: 10.1016/j.reprotox.2018.07.085. Epub 2018 Jul 26.

DOI:10.1016/j.reprotox.2018.07.085
PMID:30056207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6174104/
Abstract

Genistein is a phytoestrogen found in soy. We previously found that adult exposure to dietary levels of genistein affected gestation time, parturition time, litter size, pup weight, and pup mortality in CD-1 mice. The present study investigated the effects of adult genistein exposure on follicle number and gene expression in the ovaries of CD-1 mice. We found that exposure to genistein had no effect on follicle number, but it did affect the expression of apoptotic regulatory genes (Bax, Bcl-2, Bid, and Dffa) in the ovary.

摘要

染料木黄酮是大豆中的一种植物雌激素。我们之前发现，成年期摄入染料木黄酮会影响 CD-1 小鼠的妊娠期、分娩期、产仔数、仔鼠体重和仔鼠死亡率。本研究调查了成年期染料木黄酮暴露对 CD-1 小鼠卵巢卵泡数量和基因表达的影响。我们发现，染料木黄酮暴露对卵泡数量没有影响，但它确实影响了卵巢中凋亡调节基因（Bax、Bcl-2、Bid 和 Dffa）的表达。