Boyden Penelope A
Department of Pharmacology, Columbia University, New York, NY, 10032, USA.
J Interv Card Electrophysiol. 2018 Aug;52(3):255-262. doi: 10.1007/s10840-018-0414-3. Epub 2018 Jul 28.
There has always been an appreciation of the role of Purkinje fibers in the fast conduction of the normal cardiac impulse. Here, we briefly update our knowledge of this important set of cardiac cells. We discuss the anatomy of a Purkinje fiber strand, the importance of longitudinal conduction within a strand, circus movement within a strand, conduction, and excitability properties of Purkinjes. At the cell level, we discuss the important components of the ion channel makeup in the nonremodeled Purkinjes of healthy hearts. Finally, we discuss the role of the Purkinjes in forming the heritable arrhythmogenic substrates such as long QT, heritable conduction slowing, CPVT, sQT, and Brugada syndromes.
人们一直认识到浦肯野纤维在正常心脏冲动快速传导中的作用。在此，我们简要更新一下对这组重要心脏细胞的认识。我们讨论浦肯野纤维束的解剖结构、束内纵向传导的重要性、束内的折返运动、浦肯野纤维的传导和兴奋性特性。在细胞层面，我们讨论健康心脏未重塑的浦肯野纤维中离子通道组成的重要成分。最后，我们讨论浦肯野纤维在形成遗传性致心律失常基质（如长QT、遗传性传导减慢、儿茶酚胺敏感性多形性室性心动过速、短QT和布加综合征）中的作用。
