心脏浦肯野纤维与心律失常；2015年GK·莫伊奖讲座
Cardiac Purkinje fibers and arrhythmias; The GK Moe Award Lecture 2015.
作者信息
Boyden Penelope A, Dun Wen, Robinson Richard B
机构信息
Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, New York.
出版信息
Heart Rhythm. 2016 May;13(5):1172-1181. doi: 10.1016/j.hrthm.2016.01.011. Epub 2016 Jan 13.
Abstract
Purkinje fibers/cells continue to be a focus of arrhythmologists. Here we review several new ideas that have emerged in the literature and fold them into important new points. These points include the following: some proteins in Purkinje cells are specific to Purkinjes; pacemaker function in Purkinje may be similar to that of the sinus node cell; sink-source concerns about tracts/sheets of Purkinje fibers; role of Ito in arrhythmias; and genetic lesions in Purkinjes and their high impact on cardiac rhythm. Although new ideas about the remodeled Purkinje cell are not the focus of this review, one can easily imagine how Purkinjes and their function may be altered in diseased hearts.
摘要
浦肯野纤维/细胞仍是心律失常专家关注的焦点。在此，我们回顾文献中出现的几个新观点，并将它们整合为重要的新要点。这些要点包括：浦肯野细胞中的一些蛋白质是浦肯野细胞特有的；浦肯野细胞的起搏功能可能与窦房结细胞相似；对浦肯野纤维束/片的汇-源问题的关注；Ito在心律失常中的作用；以及浦肯野细胞中的基因损伤及其对心律的重大影响。尽管关于重塑的浦肯野细胞的新观点并非本综述的重点，但人们很容易想象浦肯野细胞及其功能在患病心脏中可能如何改变。
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本文引用的文献
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Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.利用全外显子组测序鉴定基于伊藤现象的心律失常机制及治疗方法。
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Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.伊伐布雷定可延长心脏复极化的3期，并在与阻断HCN4所需浓度范围重叠的浓度范围内阻断人ether-à-go-go相关基因1（KCNH2）电流。
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