Boyden Penelope A, Dun Wen, Robinson Richard B
Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, New York.
Heart Rhythm. 2016 May;13(5):1172-1181. doi: 10.1016/j.hrthm.2016.01.011. Epub 2016 Jan 13.
Purkinje fibers/cells continue to be a focus of arrhythmologists. Here we review several new ideas that have emerged in the literature and fold them into important new points. These points include the following: some proteins in Purkinje cells are specific to Purkinjes; pacemaker function in Purkinje may be similar to that of the sinus node cell; sink-source concerns about tracts/sheets of Purkinje fibers; role of Ito in arrhythmias; and genetic lesions in Purkinjes and their high impact on cardiac rhythm. Although new ideas about the remodeled Purkinje cell are not the focus of this review, one can easily imagine how Purkinjes and their function may be altered in diseased hearts.
浦肯野纤维/细胞仍是心律失常专家关注的焦点。在此，我们回顾文献中出现的几个新观点，并将它们整合为重要的新要点。这些要点包括：浦肯野细胞中的一些蛋白质是浦肯野细胞特有的；浦肯野细胞的起搏功能可能与窦房结细胞相似；对浦肯野纤维束/片的汇-源问题的关注；Ito在心律失常中的作用；以及浦肯野细胞中的基因损伤及其对心律的重大影响。尽管关于重塑的浦肯野细胞的新观点并非本综述的重点，但人们很容易想象浦肯野细胞及其功能在患病心脏中可能如何改变。
