Fotakopoulos George, Makris Demosthenes, Kotlia Polikceni, Kapsalaki Effie, Papanikolaou John, Georgiadis Iordanis, Zakynthinos Epaminondas, Fountas Kostas
Department of Neurosurgery, University Hospital of Thessaly, University Hospital of Larissa, Biopolis, 41110 Larissa, Thessaly, Greece.
Department of Head of Critical Care, University of Thessaly, University Hospital of Larissa, Biopolis, 41110 Larissa, Thessaly, Greece.
Future Sci OA. 2018 Jun 26;4(6):FSO313. doi: 10.4155/fsoa-2018-0015. eCollection 2018 Jul.
Early detection and diagnosis of cerebral vasospasm in subarachnoid hemorrhage may be challenging both on clinical and radiographic grounds. In this respect we conducted a pilot study in order to assess the feasibility of the technique in the everyday setting of a tertiary hospital and to evaluate the diagnostic performance of different diagnostic computed tomography perfusion aspects in diagnosing the clinical outcome of patients with subarachnoid hemorrhage. Receiver-operating characteristic analysis showed that a cerebral blood flow value of <24.5 presented 67% sensitivity and 100% specificity to diagnose adverse ischemic events at 1 month (p = 0.041). These case series data provide evidence that computed tomography perfusion-derived cerebral blood flow is a measurable index that may detect the degree of cerebral ischemia in a very early stage.
蛛网膜下腔出血时脑血管痉挛的早期检测和诊断在临床和影像学方面都可能具有挑战性。在这方面，我们进行了一项试点研究，以评估该技术在三级医院日常环境中的可行性，并评估不同诊断性计算机断层扫描灌注指标在诊断蛛网膜下腔出血患者临床结局方面的诊断性能。受试者操作特征分析表明，脑血流量值<24.5时，诊断1个月时不良缺血事件的敏感性为67%，特异性为100%（p = 0.041）。这些病例系列数据提供了证据，表明计算机断层扫描灌注衍生的脑血流量是一个可测量的指标，可在非常早期阶段检测脑缺血程度。
