Mathioudakis Nikolaos, Georgakopoulou Vasiliki Epameinondas, Paterakis Konstantinos, Papalexis Petros, Sklapani Pagona, Trakas Nikolaos, Spandidos Demetrios A, Fotakopoulos George
Department of Renal Transplantation, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Infectious Diseases and COVID-19 Unit, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Exp Ther Med. 2023 Jul 10;26(2):411. doi: 10.3892/etm.2023.12110. eCollection 2023 Aug.
Intracranial aneurysm (IA) is a common cerebrovascular disease with a high risk of rupture. At present, the mechanisms underlying the formation and rupture of IAs is not clinically clear. MicroRNAs (miRNAs/miRs) are involved in the development of IAs. The present study aimed to determine the efficacy of circulating miRNA-126 (miR-126) levels as potential biomarkers for predicting aneurysmal ruptures. The present study searched comparative articles involving circulating miR-126 levels and intracranial aneurysms through electronic databases from 1980 to February, 2023. Collected variables included the first author's name, covered study period, publication year, total number of patients and age, and number of males. We collected information about the expression levels of circulating miR-126 in serum. Three articles met the eligibility criteria. The total number of patients was 379 [226 with IA rupture and 153 with non-rupture or/+ controls (healthy)]. The circulating miR-126 can be used as a biomarker for predicting aneurysmal rupture. Interestingly, an aneurysmal size >10 mm was associated with an IA rupture.
颅内动脉瘤（IA）是一种常见的脑血管疾病，破裂风险高。目前，IA形成和破裂的潜在机制在临床上尚不清楚。微小RNA（miRNA/miR）参与IA的发展。本研究旨在确定循环miRNA-126（miR-126）水平作为预测动脉瘤破裂潜在生物标志物的有效性。本研究通过电子数据库检索了1980年至2023年2月期间涉及循环miR-126水平和颅内动脉瘤的比较文章。收集的变量包括第一作者姓名、涵盖的研究时期、出版年份、患者总数和年龄以及男性人数。我们收集了血清中循环miR-126表达水平的信息。三篇文章符合纳入标准。患者总数为379例[226例IA破裂，153例未破裂或/加对照（健康）]。循环miR-126可作为预测动脉瘤破裂的生物标志物。有趣的是，动脉瘤大小>10mm与IA破裂相关。
