利用SP6启动子的新策略克隆编码小鼠IgG1诱导因子的cDNA。
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter.
作者信息
Noma Y, Sideras P, Naito T, Bergstedt-Lindquist S, Azuma C, Severinson E, Tanabe T, Kinashi T, Matsuda F, Yaoita Y
出版信息
Nature. 1986;319(6055):640-6. doi: 10.1038/319640a0.
DOI:10.1038/319640a0
PMID:3005865
Abstract
Complementary DNA encoding the IgG1 induction factor, the first lymphokine directed to B lymphocytes, from a murine T-cell line has been cloned using a new strategy. The putative primary amino-acid sequence was deduced from the nucleotide sequence determined. The lymphokine synthesized by the direction of this cloned cDNA has many other functions, such as production of B-cell growth factor-1 and induction of Ia on B cells.
摘要
采用一种新策略，已从鼠T细胞系中克隆出编码IgG1诱导因子（第一种作用于B淋巴细胞的淋巴因子）的互补DNA。根据所确定的核苷酸序列推导了推定的一级氨基酸序列。由该克隆的互补DNA指导合成的淋巴因子具有许多其他功能，如产生B细胞生长因子-1以及诱导B细胞上Ia抗原的表达。
Zotero 插件