Coleman Michelle C, Belknap Jim K, Eades Susan C, Galantino-Homer Hannah L, Hunt Robert J, Geor Ray J, McCue Molly E, McIlwraith C Wayne, Moore Rustin M, Peroni John F, Townsend Hugh G, White Nathaniel A, Cummings Kevin J, Ivanek-Miojevic Renata, Cohen Noah D
J Am Vet Med Assoc. 2018 Aug 15;253(4):470-478. doi: 10.2460/javma.253.4.470.
OBJECTIVE To investigate risk factors for the development of pasture- and endocrinopathy-associated laminitis (PEAL) in horses and ponies in North America. DESIGN Case-control study. ANIMALS 199 horses with incident cases of PEAL and 351 horses from 2 control populations (healthy horses [n = 198] and horses with lameness not caused by laminitis [153]) that were evaluated in North America between January 2012 and December 2015 by veterinarian members of the American Association of Equine Practitioners. PROCEDURES North American members of the American Association of Equine Practitioners were contacted to participate in the study, and participating veterinarians provided historical data on incident cases of PEAL, each matched with a healthy control and a lameness control. Conditional logistic regression analysis was used to compare data on PEAL-affected horses with data on horses from each set of controls. RESULTS Horses with an obese body condition (ie, body condition score ≥ 7), generalized or regional adiposity (alone or in combination), preexisting endocrinopathy, or recent (within 30 days) glucocorticoid administration had increased odds of developing PEAL, compared with horses that did not have these findings. CONCLUSIONS AND CLINICAL RELEVANCE The present study identified several risk factors for PEAL that may assist not only in managing and preventing this form of laminitis, but also in guiding future research into its pathogenesis.
目的 调查北美马匹和矮种马发生牧场及内分泌病相关性蹄叶炎（PEAL）的风险因素。 设计 病例对照研究。 动物 199 例发生 PEAL 的马匹以及来自 2 个对照群体的 351 匹马（健康马匹 [n = 198] 和非蹄叶炎导致跛行的马匹 [153]），于 2012 年 1 月至 2015 年 12 月期间由美国马从业者协会的兽医成员在北美进行评估。 步骤 联系美国马从业者协会的北美成员参与研究，参与的兽医提供 PEAL 发病病例的历史数据，每个病例均与一匹健康对照马和一匹跛行对照马匹配。采用条件逻辑回归分析比较 PEAL 患病马的数据与每组对照马的数据。 结果 与没有这些特征的马匹相比，身体状况肥胖（即身体状况评分≥7）、全身性或局部性肥胖（单独或合并存在）、既往存在内分泌病或近期（30 天内）使用糖皮质激素的马匹发生 PEAL 的几率增加。 结论及临床意义 本研究确定了 PEAL 的几个风险因素，这不仅可能有助于管理和预防这种形式的蹄叶炎，还可为其发病机制的未来研究提供指导。
