Ménard H A, Dion J, Richard C
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):295-6.
We have studied the in vitro PHA response of two groups of rheumatoid arthritis patients differing only in the presence or absence of antinuclear antibodies. The response was depressed in positive patients and normal in negative patients. Differences in peripheral blood mononuclear cell sub-populations or lymphocytotoxic antibodies do not seem to explain this observation. Simple antinuclear antibody screening could serve as a simple method to identify a sub-group of immunodepressed rheumatoid patients as potential candidates for immunostimulating therapy.
我们研究了两组仅在是否存在抗核抗体方面存在差异的类风湿关节炎患者的体外PHA反应。阳性患者的反应受到抑制，而阴性患者的反应正常。外周血单核细胞亚群或淋巴细胞毒性抗体的差异似乎无法解释这一观察结果。简单的抗核抗体筛查可作为一种简单的方法，用于识别免疫抑制的类风湿患者亚组，作为免疫刺激治疗的潜在候选对象。
