Sdayria Jazia, Rjeibi Ilhem, Feriani Anouar, Ncib Sana, Bouguerra Wided, Hfaiedh Najla, Elfeki Abdelfattah, Allagui Mohamed Salah
Research Unit of Macromolecular Biochemistry and Genetic, Faculty of Sciences of Gafsa, University of Gafsa, 2112 Gafsa, Tunisia.
Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, University of Sfax, 3018 Sfax, Tunisia.
Pain Res Manag. 2018 Jul 4;2018:4838413. doi: 10.1155/2018/4838413. eCollection 2018.
Plants provide an alternative source to manage different human disorders due to various metabolites. The aim of this study is to investigate the phytochemical constituents of the methanolic extracts of and to evaluate their antioxidant, anti-inflammatory, and analgesic activities. The phytochemical results obtained by HPLC and by chemical assay reactions have revealed the richness of the methanolic extract of in active compounds, in particular polyphenols, flavonoids, and tannins. The methanolic extract shows significant antioxidant activities , in the DPPH and the FRAP assays. The antinociceptive activity was evaluated using acetic acid and hot-plate models of pain in mice. The anti-inflammatory activity was evaluated by carrageenan-induced paw edema. Oral pretreatment with the methanolic extract of (200 mg/kg) exhibited a significant inhibition of pain induced either by acetic acid or by the heating plate and in a manner comparable to the standard drug paracetamol. significantly reduced paw edema starting from the 3rd hour after carrageenan administration by increasing the activity of antioxidant enzymes (SOD, CAT, and GPx) in liver and paw tissues and decreasing the levels of MDA. These results may confirm the interesting potential of this plant as a treatment of various inflammatory and pain diseases.
植物因其各种代谢产物为治疗不同人类疾病提供了一种替代来源。本研究的目的是研究[植物名称]甲醇提取物的植物化学成分，并评估其抗氧化、抗炎和镇痛活性。通过高效液相色谱法（HPLC）和化学分析反应获得的植物化学结果表明，[植物名称]甲醇提取物富含活性化合物，特别是多酚、黄酮类化合物和单宁。在DPPH和FRAP试验中，甲醇提取物表现出显著的抗氧化活性。使用小鼠醋酸和热板疼痛模型评估其抗伤害感受活性。通过角叉菜胶诱导的爪肿胀来评估其抗炎活性。用[植物名称]甲醇提取物（200mg/kg）进行口服预处理，对醋酸或热板诱导的疼痛均表现出显著抑制作用，且其效果与标准药物扑热息痛相当。从角叉菜胶给药后第3小时开始，[植物名称]甲醇提取物通过提高肝脏和爪组织中抗氧化酶（超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶）的活性并降低丙二醛水平，显著减轻了爪肿胀。这些结果可能证实了这种植物在治疗各种炎症和疼痛疾病方面具有可观的潜力。
