Yamane Toshiyuki
Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine, Tsu, Japan.
Front Cell Dev Biol. 2018 Jul 20;6:80. doi: 10.3389/fcell.2018.00080. eCollection 2018.
The yolk sac is the first observed site of hematopoiesis during mouse ontogeny. Primitive erythroid cells are the most well-recognized cell lineages produced from this tissue. In addition to primitive erythroid cells, several types of hematopoietic cells are present, including multipotent hematopoietic progenitors. Yolk sac-derived blood cells constitute a transient wave of embryonic and fetal hematopoiesis. However, recent studies have demonstrated that some macrophage and B cell lineages derived from the early yolk sac may persist to adulthood. This review discusses the cellular basis of mouse yolk sac hematopoiesis and its contributions to embryonic and adult hematopoietic systems.
卵黄囊是小鼠个体发育过程中首个被观察到的造血部位。原始红细胞是源自该组织的最为人熟知的细胞谱系。除了原始红细胞外，还存在几种造血细胞类型，包括多能造血祖细胞。卵黄囊来源的血细胞构成胚胎和胎儿造血的一个短暂阶段。然而，最近的研究表明，一些源自早期卵黄囊的巨噬细胞和B细胞谱系可能持续存在至成年期。本文综述了小鼠卵黄囊造血的细胞基础及其对胚胎和成人造血系统的贡献。
