患者来源的原位小鼠模型和基因报告子在开发荧光引导手术方面的优势。
Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery.
作者信息
Lwin Thinzar M, Hoffman Robert M, Bouvet Michael
机构信息
Department of Surgery, University of California San Diego, San Diego, California.
AntiCancer, Inc, San Diego, California.
出版信息
J Surg Oncol. 2018 Aug;118(2):253-264. doi: 10.1002/jso.25150. Epub 2018 Aug 6.
Abstract
Fluorescence-guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe evaluation and highlights the advantages of patient-derived orthotopic xenografts (PDOX) mouse models and genetic reporters to develop fluorescence-guided surgery.
摘要
荧光引导手术可以提高外科医生实现完整肿瘤切除的能力。目前正在开发多种肿瘤特异性探针，并利用许多临床前小鼠模型来评估其疗效。本综述讨论了在探针评估背景下不同的临床前小鼠模型，并强调了患者来源的原位异种移植（PDOX）小鼠模型和基因报告系统在发展荧光引导手术方面的优势。
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