Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Federal University of Minas Gerais, Belo Horizonte, Brazil.
J Oral Pathol Med. 2018 Oct;47(9):816-822. doi: 10.1111/jop.12773. Epub 2018 Aug 21.
Fibroblast growth factor 2 (FGF-2) is a multifunctional cytokine expressed in several tissues and involved in a wide variety of biologic activities, with one low molecular weight (LMW) protein present in the cytosol, which is secreted, acting via its receptors (FGFRs), and four high molecular weight (HMW) proteins located in the nucleus. Fibroblast growth factor receptor (FGFR) family has four (FGFR1-4) transmembrane tyrosine kinase receptors expressed on several cell types, and FGFR-1 has been indicated as a potential molecular target in several types of cancer, including oral squamous cell carcinoma (OSCC). The FGF-2/FGFR-1 expression has been studied in the oral cavity, and it was associated with the wound repair process, the development of benign and malignant salivary gland tumors, besides being related to oral potentially malignant disorders (OPMDs) and OSCC. Hence, we critically review the currently available data on FGF-2/FGFR-1 expression in the normal mucosa and lesions of the oral cavity.
成纤维细胞生长因子 2（FGF-2）是一种多功能细胞因子，在多种组织中表达，参与广泛的生物学活性，细胞质中存在一种低分子量（LMW）蛋白，该蛋白分泌后通过其受体（FGFRs）发挥作用，还有四种高分子量（HMW）蛋白位于细胞核中。成纤维细胞生长因子受体（FGFR）家族有四个（FGFR1-4）跨膜酪氨酸激酶受体，在多种细胞类型上表达，并且 FGFR-1 已被确定为几种类型癌症的潜在分子靶标，包括口腔鳞状细胞癌（OSCC）。已经研究了口腔中 FGF-2/FGFR-1 的表达，其与伤口修复过程、良性和恶性唾液腺肿瘤的发生有关，此外还与口腔潜在恶性疾病（OPMDs）和 OSCC 有关。因此，我们批判性地回顾了目前关于口腔正常黏膜和病变中 FGF-2/FGFR-1 表达的可用数据。
