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儿童血栓形成:对谁进行何种检测、何时检测以及检测的必要性如何?

Thrombosis in children: Which test to whom, when and how much necessary?

作者信息

Celkan Tiraje, Dikme Gürcan

机构信息

İstanbul University Cerrahpaşa Medical Faculty, Department of Pediatrics, Division of Pediatric Hematology-Oncology, Istanbul, Turkey.

出版信息

Turk Pediatri Ars. 2018 Mar 1;53(1):1-9. doi: 10.5152/TurkPediatriArs.2018.2586. eCollection 2018 Mar.

Abstract

Pediatric thrombosis is multifactorial, and usually risk factors either congenital or acquired are present. After 2000, systematic reviews and meta-analysis on pediatric venous thromboembolic disease and inherited thrombophilia revealed elevated thrombotic risks in these children. In this review, we discuss thrombosis and new literature in various pediatric patient groups and the usefulness of thrombophilia testing.

摘要

儿童血栓形成是多因素的,通常存在先天性或后天性危险因素。2000年后,对儿童静脉血栓栓塞性疾病和遗传性易栓症的系统评价和荟萃分析显示,这些儿童的血栓形成风险升高。在本综述中,我们讨论了不同儿科患者群体中的血栓形成及新文献,以及易栓症检测的实用性。

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本文引用的文献

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Inherited thrombophilia: a double-edged sword.遗传性血栓形成倾向:一把双刃剑。
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):1-9. doi: 10.1182/asheducation-2016.1.1.
2
Neonatal Hemostatic Disorders: Issues and Challenges.新生儿止血障碍:问题与挑战
Semin Thromb Hemost. 2016 Oct;42(7):741-751. doi: 10.1055/s-0036-1593415. Epub 2016 Oct 5.
3
Clinical Data of Neonatal Systemic Thrombosis.新生儿全身性血栓形成的临床数据。
J Pediatr. 2016 Apr;171:60-6.e1. doi: 10.1016/j.jpeds.2015.12.035. Epub 2016 Jan 16.
4
Uncertain thrombophilia markers.不确定的血栓形成倾向标志物。
Thromb Haemost. 2016 Jan;115(1):25-30. doi: 10.1160/TH15-06-0478. Epub 2015 Aug 13.
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Renal vascular thrombosis in the newborn.新生儿肾血管血栓形成
Pediatr Nephrol. 2016 Jun;31(6):907-15. doi: 10.1007/s00467-015-3160-0. Epub 2015 Jul 15.
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Pediatric thrombophilia.小儿血栓形成倾向。
Pediatr Clin North Am. 2013 Dec;60(6):1443-62. doi: 10.1016/j.pcl.2013.09.004.

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