Pedersen N C, Johnson L, Birch D, Theilen G H
Vet Immunol Immunopathol. 1986 Feb;11(2):123-48. doi: 10.1016/0165-2427(86)90093-0.
Kittens immunized with purified native FeLV-gp70 or -gp85 envelope proteins developed ELISA, but not virus neutralizing, antibodies in their serum to both whole FeLV and FeLV-gp70. Kittens vaccinated with envelope proteins and infected with feline sarcoma virus (FeSV) developed smaller tumors than nonvaccinates, but a greater incidence of persistent retroviremia. Similarly, FeLV-gp70 and -gp85 vaccinated kittens were more apt to become persistently retroviremic following virulent FeLV challenge exposure than nonvaccinates. Kittens vaccinated with inactivated whole FeLV developed smaller tumors after FeSV inoculation and had a lower incidence of persistent retroviremia than nonvaccinates. The protective effect of inactivated whole FeLV vaccine against persistent retroviremia was also seen with FeLV challenge-exposed cats. Protection afforded by inactivated whole FeLV vaccine was not associated with virus neutralizing antibodies, although ELISA antibodies to both whole FeLV and FeLV-gp70 were induced by vaccination.
用纯化的天然猫白血病病毒糖蛋白70（FeLV-gp70）或糖蛋白85（FeLV-gp85）包膜蛋白免疫的小猫，其血清中产生了针对完整猫白血病病毒（FeLV）和FeLV-gp70的ELISA抗体，但未产生病毒中和抗体。用包膜蛋白接种疫苗并感染猫肉瘤病毒（FeSV）的小猫，其肿瘤比未接种疫苗的小猫小，但持续性逆转录病毒血症的发生率更高。同样，与未接种疫苗的小猫相比，接种FeLV-gp70和FeLV-gp85的小猫在受到强毒FeLV攻击后更易出现持续性逆转录病毒血症。用灭活的完整FeLV接种疫苗的小猫在接种FeSV后肿瘤较小，持续性逆转录病毒血症的发生率也低于未接种疫苗的小猫。在受到FeLV攻击的猫中也观察到了灭活的完整FeLV疫苗对持续性逆转录病毒血症的保护作用。灭活的完整FeLV疫苗提供的保护作用与病毒中和抗体无关，尽管接种疫苗可诱导产生针对完整FeLV和FeLV-gp70的ELISA抗体。
