• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿尔茨海默病患者外周血单个核细胞在人血脑屏障模型中控制下的趋化因子表达差异。

Differential chemokine expression under the control of peripheral blood mononuclear cells issued from Alzheimer's patients in a human blood brain barrier model.

机构信息

EA3808, molecular Targets and Therapeutics of Alzheimer's disease, University of Poitiers, Poitiers, France.

Department of Geriatrics, Poitiers University Hospital, Poitiers, France.

出版信息

PLoS One. 2018 Aug 9;13(8):e0201232. doi: 10.1371/journal.pone.0201232. eCollection 2018.

DOI:10.1371/journal.pone.0201232
PMID:30092003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6084889/
Abstract

Growing evidence highlights the peripheral blood mononuclear cells (PBMCs) role and the chemokine involvement in the Alzheimer's disease (AD) physiopathology. However, few data are available about the impact of AD PBMCs in the chemokine signature in a brain with AD phenotype. Therefore, this study analyzed the chemokine levels in a human blood brain barrier model. A human endothelial cell line from the immortalized cerebral microvascular endothelial cell line (hCMEC/D3) and a human glioblastoma U-87 MG cell line, both with no AD phenotype were used while PBMCs came from AD at mild or moderate stage and control patients. PBMCs from moderate AD patients decreased CCL2 and CCL5 levels in endothelial, and also CXCL10 in abluminal compartments and in PBMCs compared to PBMCs from mild AD patients. The CX3CL1 expression increased in endothelial and abluminal compartments with PBMCs from mild AD patients compared to controls. AD PBMCs can convert the chemokine signature towards that found in AD brain, targeting some chemokines as new biomarkers in AD.

摘要

越来越多的证据强调了外周血单核细胞（PBMCs）在阿尔茨海默病（AD）病理生理学中的作用和趋化因子的参与。然而，关于 AD PBMCs 在具有 AD 表型的大脑中的趋化因子特征中的影响的数据很少。因此，本研究分析了人类血脑屏障模型中的趋化因子水平。使用了来自永生化脑微血管内皮细胞系（hCMEC/D3）的人内皮细胞系和人神经胶质瘤 U-87 MG 细胞系，两者均无 AD 表型，而 PBMCs 来自轻度或中度 AD 患者和对照患者。与轻度 AD 患者的 PBMCs 相比，来自中度 AD 患者的 PBMCs 降低了内皮细胞中的 CCL2 和 CCL5 水平，以及基底外侧隔室和 PBMCs 中的 CXCL10 水平。与对照组相比，来自轻度 AD 患者的 PBMCs 增加了内皮细胞和基底外侧隔室中的 CX3CL1 表达。AD PBMCs 可以将趋化因子特征转化为 AD 大脑中发现的特征，将某些趋化因子作为 AD 的新生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/3917b8ff9828/pone.0201232.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/b96ede38eba5/pone.0201232.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/70fad1bf8bfb/pone.0201232.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/7658e9ea9e6b/pone.0201232.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/3917b8ff9828/pone.0201232.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/b96ede38eba5/pone.0201232.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/70fad1bf8bfb/pone.0201232.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/7658e9ea9e6b/pone.0201232.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4943/6084889/3917b8ff9828/pone.0201232.g004.jpg

相似文献

1
Differential chemokine expression under the control of peripheral blood mononuclear cells issued from Alzheimer's patients in a human blood brain barrier model.阿尔茨海默病患者外周血单个核细胞在人血脑屏障模型中控制下的趋化因子表达差异。
PLoS One. 2018 Aug 9;13(8):e0201232. doi: 10.1371/journal.pone.0201232. eCollection 2018.
2
Peripheral Blood Mononuclear Cells of Alzheimer's Disease Patients Control CCL4 and CXCL10 Levels in a Human Blood Brain Barrier Model.阿尔茨海默病患者的外周血单核细胞在人血脑屏障模型中控制CCL4和CXCL10水平。
Curr Alzheimer Res. 2017;14(11):1215-1228. doi: 10.2174/1567205014666170417110337.
3
Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice.阿尔茨海默病转基因与野生型小鼠血脑屏障模型中趋化因子的纵向表达谱。
J Neuroinflammation. 2018 Jun 13;15(1):182. doi: 10.1186/s12974-018-1220-7.
4
Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease.外周趋化因子受体、其配体、细胞因子与阿尔茨海默病
J Alzheimers Dis. 2008 Jun;14(2):147-59. doi: 10.3233/jad-2008-14203.
5
Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease.阿尔茨海默病患者外周血单个核细胞中两种选定β趋化因子的表达与产生
Exp Gerontol. 2005 Jul;40(7):605-11. doi: 10.1016/j.exger.2005.04.007.
6
Evaluation of serum levels of chemokines during interferon-β treatment in multiple sclerosis patients: a 1-year, observational cohort study.多发性硬化症患者干扰素-β治疗期间趋化因子血清水平评估：一项为期 1 年的观察性队列研究。
CNS Drugs. 2011 Nov 1;25(11):971-81. doi: 10.2165/11595060-000000000-00000.
7
Cerebrospinal Fluid and Blood CX3CL1 as a Potential Biomarker in Early Diagnosis and Prognosis of Dementia.脑脊液和血液 CX3CL1 作为早期诊断和预测痴呆症的潜在生物标志物。
Curr Alzheimer Res. 2020;17(8):709-721. doi: 10.2174/1567205017666201109095657.
8
Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells.μ阿片类物质诱导人外周血单个核细胞中单核细胞趋化蛋白-1、调节激活正常T细胞表达和分泌的因子及γ干扰素诱导蛋白-10的表达
J Immunol. 2000 Dec 1;165(11):6519-24. doi: 10.4049/jimmunol.165.11.6519.
9
Early alterations in blood and brain RANTES and MCP-1 expression and the effect of exercise frequency in the 3xTg-AD mouse model of Alzheimer's disease.阿尔茨海默病3xTg-AD小鼠模型中血液和大脑RANTES及MCP-1表达的早期变化以及运动频率的影响
Neurosci Lett. 2016 Jan 1;610:165-70. doi: 10.1016/j.neulet.2015.11.002. Epub 2015 Nov 4.
10
[THE ROLE OF CYTOKINES AND CHEMOKINES IN LABORATORY DIAGNOSTIC OF CHRONIC VIRAL HEPATITIS C].[细胞因子和趋化因子在丙型慢性病毒性肝炎实验室诊断中的作用]
Klin Lab Diagn. 2015 Aug;60(8):45-51.

引用本文的文献

1
CX3CL1 Regulation of Gliosis in Neuroinflammatory and Neuroprotective Processes.CX3CL1在神经炎症和神经保护过程中对神经胶质增生的调节
Int J Mol Sci. 2025 Jan 23;26(3):959. doi: 10.3390/ijms26030959.
2
T Cells Trafficking into the Brain in Aging and Alzheimer's Disease.T 细胞在衰老和阿尔茨海默病中向大脑的迁移。
J Neuroimmune Pharmacol. 2024 Aug 24;19(1):47. doi: 10.1007/s11481-024-10147-5.
3
Chemokines in patients with Alzheimer's disease: A meta-analysis.阿尔茨海默病患者体内的趋化因子：一项荟萃分析。

本文引用的文献

1
The role of the immune system in Alzheimer disease: Etiology and treatment.免疫系统在阿尔茨海默病中的作用：病因与治疗。
Ageing Res Rev. 2017 Nov;40:84-94. doi: 10.1016/j.arr.2017.08.005. Epub 2017 Sep 21.
2
Early and Late CNS Inflammation in Alzheimer's Disease: Two Extremes of a Continuum?阿尔茨海默病的中枢神经系统早期和晚期炎症：是连续体的两个极端吗？
Trends Pharmacol Sci. 2017 Nov;38(11):956-966. doi: 10.1016/j.tips.2017.07.005. Epub 2017 Aug 31.
3
Microglia in Alzheimer's disease.阿尔茨海默病中的小胶质细胞。
Front Aging Neurosci. 2023 Mar 9;15:1047810. doi: 10.3389/fnagi.2023.1047810. eCollection 2023.
4
Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease.阿尔茨海默病中NLRP3炎性小体激活的药理学和表观遗传学调节因子
Pharmaceuticals (Basel). 2021 Nov 20;14(11):1187. doi: 10.3390/ph14111187.
5
Regulated upon activation, normal T cell expressed and secreted (RANTES) levels in the peripheral blood of patients with Alzheimer's disease.阿尔茨海默病患者外周血中活化调节正常T细胞表达和分泌因子（RANTES）水平
Neural Regen Res. 2021 Apr;16(4):796-800. doi: 10.4103/1673-5374.295340.
6
Study of the effects of adapted Tango and multidimensional intervention in pREvention of dementia in agiNG: developing healTHy lifestyle programs (STRENGTH Project)-the experimental protocol of a prospective randomised controlled trial.适应探戈舞和多维干预对延缓老年人痴呆的效果研究：制定健康生活方式方案（STRENGTH 项目）——一项前瞻性随机对照试验的实验方案。
Aging Clin Exp Res. 2020 Dec;32(12):2529-2537. doi: 10.1007/s40520-020-01504-4. Epub 2020 Mar 2.
J Clin Invest. 2017 Sep 1;127(9):3240-3249. doi: 10.1172/JCI90606.
4
Biomarkers for Alzheimer Disease: Classical and Novel Candidates' Review.阿尔茨海默病的生物标志物：经典和新型候选物的综述。
Neuroscience. 2018 Feb 1;370:181-190. doi: 10.1016/j.neuroscience.2017.07.017. Epub 2017 Jul 17.
5
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.阿尔茨海默病中的脑血流调节与神经血管功能障碍
Nat Rev Neurosci. 2017 Jul;18(7):419-434. doi: 10.1038/nrn.2017.48. Epub 2017 May 18.
6
Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis.炎症分子在阿尔茨海默病进展和诊断中的作用。
J Neurol Sci. 2017 May 15;376:242-254. doi: 10.1016/j.jns.2017.03.031. Epub 2017 Mar 22.
7
Applying fluid biomarkers to Alzheimer's disease.将流体生物标志物应用于阿尔茨海默病
Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C3-C10. doi: 10.1152/ajpcell.00007.2017. Epub 2017 Apr 19.
8
Peripheral Blood Mononuclear Cells of Alzheimer's Disease Patients Control CCL4 and CXCL10 Levels in a Human Blood Brain Barrier Model.阿尔茨海默病患者的外周血单核细胞在人血脑屏障模型中控制CCL4和CXCL10水平。
Curr Alzheimer Res. 2017;14(11):1215-1228. doi: 10.2174/1567205014666170417110337.
9
Association of the CX3CR1-V249I Variant with Neurofibrillary Pathology Progression in Late-Onset Alzheimer's Disease.CX3CR1-V249I 变异与晚发性阿尔茨海默病神经纤维缠结病理进展的关联。
Mol Neurobiol. 2018 Mar;55(3):2340-2349. doi: 10.1007/s12035-017-0489-3. Epub 2017 Mar 25.
10
T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers.T 淋巴细胞和炎症介质在阿尔茨海默病脑-血相互作用中的作用：新生物标志物的潜在来源。
J Immunol Res. 2017;2017:4626540. doi: 10.1155/2017/4626540. Epub 2017 Feb 15.