Wang Hecheng, Zong Yu, Zhu Lei, Wang Weiyi, Han Yanshuo
School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China.
Department of Cardiovascular Diseases, Civil Aviation General Hospital, Peking University, Beijing, China.
Front Aging Neurosci. 2023 Mar 9;15:1047810. doi: 10.3389/fnagi.2023.1047810. eCollection 2023.
Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly people. Many researches have reported that neuroinflammation is related to AD. Chemokines are a class of small cytokines that play important roles in cell migration and cell communication, which involved in neuroinflammation. Up to now there is no meta-analysis to explore the difference of chemokines between AD patients and healthy elderly individuals.
We searched PubMed, Web of science, Cochrane library, EMBASE and Scopus databases from inception to January 2022. Data were extracted by two independent reviewers, and the Review Manager 5.3 was used for the meta-analysis.
Thirty-two articles were included and analyzed. The total number of participants in the included study was 3,331. We found that the levels of CCL5 (SMD = 2.56, 95% CI: 1.91-3.21), CCL15 (SMD = 3.30, 95% CI: 1.48-5.13) and IP-10 (SMD = 3.88, 95% CI: 1.84-5.91) in the plasma of AD patients were higher than healthy people. MCP-1 protein (SMD = 0.67, 95% CI: 0.29-1.05) in the AD patients' CSF was higher than healthy controls.
These results suggested that chemokines may play an important role in AD. These findings could provide evidences for the diagnosis and treatment of AD.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278736, identifier: CRD42021278736.
阿尔茨海默病（AD）是老年人中最常见的神经退行性疾病。许多研究报告称神经炎症与AD有关。趋化因子是一类在细胞迁移和细胞通讯中起重要作用的小分子细胞因子，参与神经炎症。到目前为止，尚无荟萃分析探讨AD患者与健康老年人之间趋化因子的差异。
我们检索了从数据库建立至2022年1月的PubMed、科学网、Cochrane图书馆、EMBASE和Scopus数据库。由两名独立的审阅者提取数据，并使用Review Manager 5.3进行荟萃分析。
纳入并分析了32篇文章。纳入研究的参与者总数为3331人。我们发现，AD患者血浆中CCL5（标准化均数差=2.56，95%置信区间：1.91-3.21）、CCL15（标准化均数差=3.30，95%置信区间：1.48-5.13）和IP-10（标准化均数差=3.88，95%置信区间：1.84-5.91）的水平高于健康人。AD患者脑脊液中的MCP-1蛋白（标准化均数差=0.67，95%置信区间：0.29-1.05）高于健康对照。
这些结果表明趋化因子可能在AD中起重要作用。这些发现可为AD的诊断和治疗提供证据。
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278736，标识符：CRD42021278736。
