Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.
Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, PR China.
Carbohydr Polym. 2018 Oct 15;198:86-93. doi: 10.1016/j.carbpol.2018.06.058. Epub 2018 Jun 18.
Polyelectrolyte complex (PECs) hydrogels with high hygroscopicity modulation ability were successfully prepared based on carboxymethyl chitosan (CMCS)/alginate. The swelling ratio of the hydrogels could be tuned from 1 to 450 simply by changing the weight ratio of CMCS to alginate, and superabsorbent hydrogels were obtained when the weight ratio of CMCS to alginate was below 1/1. Also, the swelling kinetics and water diffusion mechanism in the hydrogels were discussed. In vitro cytotoxicity results indicated that hydrogels had excellent cytocompatibility. The swelling ratio of the hydrogel as well as its BSA releasing profile was notably pH dependent. Compared with the values at pH 1.2, the swelling ratio of hydrogels (CMCS/alginate weight ratio of 1/2) at pH 7.4 was about 34 times higher, and the amount of BSA released at pH 7.4 was also significantly higher. The as-prepared CMCS/alginate PECs hydrogels hold great potential for oral delivery of protein drugs through the intestinal tract.
基于羧甲基壳聚糖（CMCS）/海藻酸钠成功制备了具有高吸湿性调节能力的聚电解质复合物（PECs）水凝胶。通过简单地改变 CMCS 与海藻酸钠的重量比，水凝胶的溶胀比可从 1 调至 450，当 CMCS 与海藻酸钠的重量比低于 1/1 时，可得到超吸水性水凝胶。还讨论了水凝胶中的溶胀动力学和水分扩散机制。体外细胞毒性结果表明水凝胶具有优异的细胞相容性。水凝胶的溶胀率及其 BSA 释放特性明显依赖于 pH 值。与在 pH 值 1.2 时的数值相比，在 pH 值 7.4 时水凝胶（CMCS/海藻酸钠重量比为 1/2）的溶胀率约高 34 倍，在 pH 值 7.4 时释放的 BSA 量也明显更高。所制备的 CMCS/海藻酸钠 PECs 水凝胶在通过肠道进行蛋白质药物的口服递送方面具有很大的潜力。
