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细胞膜放射生物学的新进展及其对辐射防护的影响。

New aspects of cell membrane radiobiology and their impact on radiation protection.

作者信息

Köteles G J

出版信息

At Energy Rev. 1979 Mar;17(1):3-30.

PMID:385011
Abstract

Recent developments in the field of the membrane biology of eukaryotic cells have revived relevant radiobiological studies. The supramolecular structures of membranes built up by the various chemical components that ensure certain functions and connections of the cells seem to react sensitively to ionizing radiations. Data concerning those radiation-induced alterations that reflect changes of such features and functions as surface charges, membrane-bound enzyme activities and receptor functions are reviewed. As the new concepts arising from the results obtained so far may have consequences in the theory and practice of radiation protection, a few areas are mentioned where the impact of the relevant accumulated knowledge might be expected to result in practical applications.

摘要

真核细胞膜生物学领域的最新进展使相关放射生物学研究得以复兴。由确保细胞特定功能和连接的各种化学成分构建而成的膜超分子结构,似乎对电离辐射反应敏感。本文综述了有关辐射诱导变化的数据,这些变化反映了诸如表面电荷、膜结合酶活性和受体功能等特征和功能的改变。鉴于目前所获结果产生的新概念可能对辐射防护的理论和实践产生影响,文中提及了几个领域,预计相关积累知识的影响可能会带来实际应用。

相似文献

1
New aspects of cell membrane radiobiology and their impact on radiation protection.细胞膜放射生物学的新进展及其对辐射防护的影响。
At Energy Rev. 1979 Mar;17(1):3-30.
2
Utility of biological membranes as indicators for radiation exposure: alterations in membrane structure and function over time.生物膜作为辐射暴露指标的效用:膜结构和功能随时间的变化
Stem Cells. 1995 May;13 Suppl 1:142-52.
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Membrane effects of ionizing radiation and hyperthermia.电离辐射和热疗的膜效应。
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 May;49(5):743-70. doi: 10.1080/09553008514552971.
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[Structural changes in the plasma membrane as affected by ionizing radiation].
Usp Sovrem Biol. 1982 Mar-Apr;93(2):183-95.
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The effects of low doses of ionizing radiation upon the micromorphology and functional state of cell surface.低剂量电离辐射对细胞表面微观形态和功能状态的影响。
Scanning Microsc. 1987 Sep;1(3):1267-78.
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Radiation-induced bystander effects. Mechanisms, biological implications, and current investigations at the Leipzig LIPSION facility.辐射诱导的旁观者效应。莱比锡LIPSION设施的作用机制、生物学意义及当前研究
Strahlenther Onkol. 2003 Feb;179(2):69-77. doi: 10.1007/s00066-003-1000-9.
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Alterations in the structure and function of the mammalian cell membrane after exposure to ionizing radiation.暴露于电离辐射后哺乳动物细胞膜的结构和功能变化。
Scan Electron Microsc. 1981;4:47-54.
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The effects of ionizing radiation on biomembrane structure and function.电离辐射对生物膜结构与功能的影响。
Prog Biophys Mol Biol. 1984;43(1):71-93. doi: 10.1016/0079-6107(84)90004-x.
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An overview of recent charged-particle radiation biology in Italy.意大利近期带电粒子辐射生物学概述。
Phys Med. 2001;17 Suppl 1:278-82.
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Fluidity of cell membranes--current concepts and trends.细胞膜的流动性——当前概念与趋势
Int Rev Cytol. 1979;60:121-47.

引用本文的文献

1
Effects of mixed neutron-gamma irradiation in vivo on the cell surfaces of murine blood cells.体内混合中子-γ射线辐照对小鼠血细胞表面的影响。
Radiat Environ Biophys. 1984;23(4):269-77. doi: 10.1007/BF01407598.
2
Repair of membrane damage in X-irradiated E. coli.X射线照射的大肠杆菌中膜损伤的修复
Br J Cancer Suppl. 1984;6:129-34.
3
Effects of radioprotectors on the cAMP and cGMP systems.辐射防护剂对环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)系统的影响。
Radiat Environ Biophys. 1984;23(2):79-93. doi: 10.1007/BF01213732.