• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对分离出的人巨细胞病毒包膜蛋白的免疫反应。

Immune responses to isolated human cytomegalovirus envelope proteins.

作者信息

Gönczöl E, Hudecz F, Ianacone J, Dietzschold B, Starr S, Plotkin S A

出版信息

J Virol. 1986 May;58(2):661-4. doi: 10.1128/JVI.58.2.661-664.1986.

DOI:10.1128/JVI.58.2.661-664.1986
PMID:3009877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC252959/
Abstract

A group of envelope proteins of human cytomegalovirus, gA protein (L. Pereira, M. Hoffman, M. Tatsuno, and D. Dondero, Virology 139:73-86, 1984; L. Pereira, p. 383-404, in B. Roizman, ed., The herpesviruses, vol. 3, 1985), and two protein mixtures (58,000-molecular-weight [58K]-66K and 130K-66K), separated by serial columns prepared with anti-gA immunoglobulin G from sera of immunized guinea pigs, induced neutralizing antibodies and a cellular immune response in the animals. The gA is a disulfide-linked protein complex consisting of high-molecular-weight (greater than 200K), 130K-150K, and 55K-58K proteins.

摘要

一组人巨细胞病毒包膜蛋白、gA蛋白（L. 佩雷拉、M. 霍夫曼、M. 龙野和D. 唐德罗，《病毒学》139:73 - 86，1984年；L. 佩雷拉，第383 - 404页，载于B. 罗伊兹曼编，《疱疹病毒》，第3卷，1985年），以及两种蛋白质混合物（分子量58,000 [58K] - 66K和130K - 66K），通过用来自免疫豚鼠血清的抗gA免疫球蛋白G制备的串联柱分离，在动物体内诱导出中和抗体和细胞免疫反应。gA是一种由高分子量（大于200K）、130K - 150K和55K - 58K蛋白质组成的二硫键连接的蛋白质复合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/a568a0122e18/jvirol00110-0437-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/d73befa214ef/jvirol00110-0436-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/a53b6f73ae97/jvirol00110-0436-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/cb6bb0a25b0b/jvirol00110-0436-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/a568a0122e18/jvirol00110-0437-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/d73befa214ef/jvirol00110-0436-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/a53b6f73ae97/jvirol00110-0436-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/cb6bb0a25b0b/jvirol00110-0436-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18b/252959/a568a0122e18/jvirol00110-0437-a.jpg

相似文献

1
Immune responses to isolated human cytomegalovirus envelope proteins.对分离出的人巨细胞病毒包膜蛋白的免疫反应。
J Virol. 1986 May;58(2):661-4. doi: 10.1128/JVI.58.2.661-664.1986.
2
Preparation of highly purified human cytomegalovirus envelope antigen.高纯度人巨细胞病毒包膜抗原的制备。
Vaccine. 1985 Sep;3(3):300-4. doi: 10.1016/s0264-410x(85)90119-7.
3
Induction of human cytomegalovirus (HCMV)-glycoprotein B (gB)-specific neutralizing antibody and phosphoprotein 65 (pp65)-specific cytotoxic T lymphocyte responses by naked DNA immunization.通过裸DNA免疫诱导人巨细胞病毒（HCMV）-糖蛋白B（gB）特异性中和抗体和磷蛋白65（pp65）特异性细胞毒性T淋巴细胞反应。
Vaccine. 1999 Jan;17(1):50-8. doi: 10.1016/s0264-410x(98)00145-5.
4
Isolated gA/gB glycoprotein complex of human cytomegalovirus envelope induces humoral and cellular immune-responses in human volunteers.人巨细胞病毒包膜的分离gA/gB糖蛋白复合物在人类志愿者中诱导体液免疫和细胞免疫反应。
Vaccine. 1990 Apr;8(2):130-6. doi: 10.1016/0264-410x(90)90135-9.
5
Human cytomegalovirus polypeptides stimulate neutralizing antibody in vivo.人巨细胞病毒多肽在体内刺激中和抗体产生。
Virology. 1985 Aug;145(1):186-90. doi: 10.1016/0042-6822(85)90215-6.
6
HCMV envelope antigens induce both humoral and cellular immunity in guinea pigs.
Proc Soc Exp Biol Med. 1984 Feb;175(2):243-50. doi: 10.3181/00379727-175-41796.
7
Neutralizing antibodies detect a disulfide-linked glycoprotein complex within the envelope of human cytomegalovirus.中和抗体可检测到人巨细胞病毒包膜内一种二硫键连接的糖蛋白复合物。
Virology. 1984 Jun;135(2):369-78. doi: 10.1016/0042-6822(84)90193-4.
8
Immunogenicity evaluation of DNA vaccines that target guinea pig cytomegalovirus proteins glycoprotein B and UL83.针对豚鼠巨细胞病毒蛋白糖蛋白B和UL83的DNA疫苗的免疫原性评估。
Viral Immunol. 2000;13(2):155-67. doi: 10.1089/vim.2000.13.155.
9
Analysis of human antibody responses to human cytomegalovirus envelope glycoproteins found in two families of disulfide linked glycoprotein complexes designated gC-I and gC-II.
Arch Virol. 1990;114(3-4):213-28. doi: 10.1007/BF01310750.
10
Recombinant modified vaccinia virus Ankara expressing a soluble form of glycoprotein B causes durable immunity and neutralizing antibodies against multiple strains of human cytomegalovirus.表达可溶性糖蛋白B的重组改良安卡拉痘苗病毒可诱导针对多种人类巨细胞病毒株的持久免疫力和中和抗体。
J Virol. 2004 Apr;78(8):3965-76. doi: 10.1128/jvi.78.8.3965-3976.2004.

引用本文的文献

1
The history of vaccination against cytomegalovirus.抗巨细胞病毒疫苗接种史。
Med Microbiol Immunol. 2015 Jun;204(3):247-54. doi: 10.1007/s00430-015-0388-z. Epub 2015 Mar 20.
2
Column liquid chromatography of integral membrane proteins.整合膜蛋白的柱液相色谱法。
J Chromatogr. 1987 Jul 17;418:223-43. doi: 10.1016/0378-4347(87)80010-5.
3
Antigenic cross-reactions among herpes simplex virus types 1 and 2, Epstein-Barr virus, and cytomegalovirus.1型和2型单纯疱疹病毒、爱泼斯坦-巴尔病毒及巨细胞病毒之间的抗原交叉反应。

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Neutralizing antibodies detect a disulfide-linked glycoprotein complex within the envelope of human cytomegalovirus.中和抗体可检测到人巨细胞病毒包膜内一种二硫键连接的糖蛋白复合物。
Virology. 1984 Jun;135(2):369-78. doi: 10.1016/0042-6822(84)90193-4.
3
Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins.针对人巨细胞病毒病毒体蛋白的单克隆抗体和多克隆免疫血清的特性分析
J Virol. 1987 Apr;61(4):1125-35. doi: 10.1128/JVI.61.4.1125-1135.1987.
4
Marek's disease virus serotype-1 antigens A and B and their unglycosylated precursors detected by Western blot analysis of infected cells.通过对感染细胞的蛋白质免疫印迹分析检测到的1型马立克氏病病毒抗原A和B及其未糖基化前体。
Virus Genes. 1988 Oct;2(1):5-18. doi: 10.1007/BF00569733.
5
Induction of complement-dependent and -independent neutralizing antibodies by recombinant-derived human cytomegalovirus gp55-116 (gB).重组人巨细胞病毒gp55 - 116（gB）诱导补体依赖性和非依赖性中和抗体
J Virol. 1988 Sep;62(9):3309-18. doi: 10.1128/JVI.62.9.3309-3318.1988.
6
Identification and expression of a human cytomegalovirus glycoprotein with homology to the Epstein-Barr virus BXLF2 product, varicella-zoster virus gpIII, and herpes simplex virus type 1 glycoprotein H.一种与爱泼斯坦-巴尔病毒BXLF2产物、水痘-带状疱疹病毒gpIII及单纯疱疹病毒1型糖蛋白H具有同源性的人巨细胞病毒糖蛋白的鉴定与表达
J Virol. 1988 Apr;62(4):1416-22. doi: 10.1128/JVI.62.4.1416-1422.1988.
7
Identification and characterization of three distinct families of glycoprotein complexes in the envelopes of human cytomegalovirus.人巨细胞病毒包膜中三种不同糖蛋白复合物家族的鉴定与表征。
J Virol. 1988 Mar;62(3):875-81. doi: 10.1128/JVI.62.3.875-881.1988.
8
Human immune responses to major human cytomegalovirus glycoprotein complexes.人类对主要人巨细胞病毒糖蛋白复合体的免疫反应。
J Virol. 1988 Mar;62(3):1066-70. doi: 10.1128/JVI.62.3.1066-1070.1988.
9
Sequence requirements for proteolytic processing of glycoprotein B of human cytomegalovirus strain Towne.人巨细胞病毒汤氏株糖蛋白B蛋白水解加工的序列要求
J Virol. 1990 Jun;64(6):2922-31. doi: 10.1128/JVI.64.6.2922-2931.1990.
10
Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response.人巨细胞病毒（HCMV）gp55 - 116（gB）的细胞表面表达：在分析人中和抗体反应中使用HCMV重组痘苗病毒感染的细胞
J Virol. 1990 Mar;64(3):1079-85. doi: 10.1128/JVI.64.3.1079-1085.1990.
Virology. 1984 Jan 30;132(2):325-38. doi: 10.1016/0042-6822(84)90039-4.
4
HCMV envelope antigens induce both humoral and cellular immunity in guinea pigs.
Proc Soc Exp Biol Med. 1984 Feb;175(2):243-50. doi: 10.3181/00379727-175-41796.
5
"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.“蛋白质免疫印迹法”：蛋白质从十二烷基硫酸钠 - 聚丙烯酰胺凝胶电泳转移至未修饰的硝酸纤维素膜上，并用抗体和放射性碘化蛋白A进行放射自显影检测。
Anal Biochem. 1981 Apr;112(2):195-203. doi: 10.1016/0003-2697(81)90281-5.
6
Polymorphism of human cytomegalovirus glycoproteins characterized by monoclonal antibodies.用单克隆抗体鉴定人巨细胞病毒糖蛋白的多态性。
Virology. 1984 Nov;139(1):73-86. doi: 10.1016/0042-6822(84)90331-3.
7
Localization and synthesis of an antigenic determinant of herpes simplex virus glycoprotein D that stimulates the production of neutralizing antibody.单纯疱疹病毒糖蛋白D刺激中和抗体产生的抗原决定簇的定位与合成。
J Virol. 1984 Jan;49(1):102-8. doi: 10.1128/JVI.49.1.102-108.1984.
8
Monoclonal antibodies to human cytomegalovirus: three surface membrane proteins with unique immunological and electrophoretic properties specify cross-reactive determinants.抗人巨细胞病毒单克隆抗体：三种具有独特免疫和电泳特性的表面膜蛋白可确定交叉反应决定簇。
Infect Immun. 1982 Jun;36(3):924-32. doi: 10.1128/iai.36.3.924-932.1982.
9
Silver staining of proteins in polyacrylamide gels.聚丙烯酰胺凝胶中蛋白质的银染法。
Anal Biochem. 1981 Nov 15;118(1):197-203. doi: 10.1016/0003-2697(81)90179-2.
10
Towne-vaccine-induced prevention of cytomegalovirus disease after renal transplants.托恩疫苗诱导预防肾移植后巨细胞病毒疾病。
Lancet. 1984 Mar 10;1(8376):528-30. doi: 10.1016/s0140-6736(84)90930-9.