人巨细胞病毒多肽在体内刺激中和抗体产生。
Human cytomegalovirus polypeptides stimulate neutralizing antibody in vivo.
作者信息
Rasmussen L, Mullenax J, Nelson M, Merigan T C
出版信息
Virology. 1985 Aug;145(1):186-90. doi: 10.1016/0042-6822(85)90215-6.
At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for immunogenicity in guinea pigs. Neutralizing antibody was detected after immunization with both p86 and p130/55. Hyperimmune sera to p130/55, but not p86, were dependent upon guinea pig complement for virus neutralization.
至少三种人巨细胞病毒多肽是病毒中和抗体的靶标；一种分子量为86,000的单一蛋白质（p86）以及两种分子量分别为130,000和55,000的共免疫沉淀蛋白质（p130/55）。这些多肽已通过免疫亲和层析分离，并在豚鼠中测试了免疫原性。用p86和p130/55免疫后均检测到中和抗体。针对p130/55而非p86的超免疫血清的病毒中和作用依赖于豚鼠补体。
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