van Haeringen N J, Glasius E
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Mar 29;202(1):1-7. doi: 10.1007/BF00496763.
Concentrations of the metabolites glucose, lactate, pyruvate, and urea were determined in human tear fluid. Collection of the tears in glass capillaries, without mechanical irritation, permitted the estimation of naturally occurring levels of these metabolites. Glucose concentrations were very low, also in diabetics with high blood glucose levels. Lactate was present at higher levels and pyruvate and urea in about the same concentrations as normally for blood. Collection of the tears with filter paper strips as absorbent material caused slight epithelial damage and consequently a loss of the barrier function of the epithelium. In filter paper eluates glucose concentrations were found to be much higher, especially in diabetics with high blood glucose levels. Lactate and pyruvate concentrations were not influenced, whereas the urea concentrations decreased. The value of clinical tear glucose tests is discussed.
测定了人泪液中葡萄糖、乳酸、丙酮酸和尿素等代谢物的浓度。在无机械刺激的情况下，用玻璃毛细管收集眼泪，从而能够估算这些代谢物的自然水平。葡萄糖浓度非常低，血糖水平高的糖尿病患者亦是如此。乳酸水平较高，丙酮酸和尿素的浓度与正常血液中的浓度大致相同。用滤纸作为吸收材料收集眼泪会造成轻微的上皮损伤，进而导致上皮屏障功能丧失。在滤纸洗脱液中，发现葡萄糖浓度要高得多，尤其是血糖水平高的糖尿病患者。乳酸和丙酮酸浓度不受影响，而尿素浓度降低。文中讨论了临床泪液葡萄糖检测的价值。
