National Institute of Malaria Research, Sector 8 Dwarka, New Delhi, 110077, India.
Kumaun University, Nainital, 263001, India.
Int J Infect Dis. 2018 Sep;74:41-46. doi: 10.1016/j.ijid.2018.06.020. Epub 2018 Jul 2.
To study the epidemiology of dengue with reference to serological, demographic profile, spatio-temporal distribution, vectors, circulating serotypes and coinfections.
Demographic data and presenting symptoms of fever cases reporting to the clinic were recorded. Suspected patients were tested for dengue, chikungunya and malaria. Dengue specific RT-PCR was performed to detect circulating DENV serotypes. Vector surveys were carried out to detect Aedes breeding.
Of the 5536 fever patients tested during 2012 to 2015, 1536 (27.7%) had confirmed dengue. The peak in dengue positivity was observed during September and October. Of the 60 samples analysed, 10 (16.7%) had concurrent infection with multiple dengue serotypes; one of them had all the four serotypes. Coinfection of dengue with malaria and chikungunya was also observed. The occurrence of dengue and malaria was inversely related. Seven percent of the dengue patients required hospitalization. Vector surveys in the draining area revealed Aedes breeding with a high house index.
Delhi being hyperendemic, the occurrence of concurrent infections with multiple DENV serotypes has become a frequent finding. The study emphasizes the need of epidemiological and entomological surveillance to monitor trends in dengue distribution, seasonal patterns and circulating serotypes to guide dengue control activities.
研究登革热的流行病学，参考血清学、人口统计学特征、时空分布、媒介、循环血清型和合并感染。
记录就诊的发热病例的人口统计学数据和临床表现。对疑似患者进行登革热、基孔肯雅热和疟疾检测。进行登革热特异性 RT-PCR 以检测循环 DENV 血清型。进行媒介调查以检测伊蚊滋生情况。
在 2012 年至 2015 年期间检测的 5536 例发热患者中，有 1536 例（27.7%）确诊为登革热。登革热阳性率的高峰出现在 9 月和 10 月。在分析的 60 个样本中，有 10 个（16.7%）同时感染了多种登革热血清型；其中一个同时感染了所有 4 种血清型。登革热与疟疾和基孔肯雅热的合并感染也有观察到。登革热和疟疾的发生呈负相关。7%的登革热患者需要住院治疗。引流区的媒介调查显示存在高房屋指数的伊蚊滋生。
德里是高度流行地区，多种 DENV 血清型同时感染的情况已成为常见现象。本研究强调需要进行流行病学和昆虫学监测，以监测登革热分布趋势、季节性模式和循环血清型，从而指导登革热控制活动。
