School of Biological and Health Sciences, Technological University Dublin (TU Dublin)-City Campus, Kevin Street D08 NF82, Ireland.
engCORE, Faculty of Engineering, Institute of Technology Carlow, Kilkenny Road, Carlow R93 V960, Ireland.
Molecules. 2020 Feb 14;25(4):833. doi: 10.3390/molecules25040833.
Haemostatic disorders are both complex and costly in relation to both their treatment and subsequent management. As leading causes of mortality worldwide, there is an ever-increasing drive to improve the diagnosis and prevention of haemostatic disorders. The field of microfluidic and Lab on a Chip (LOC) technologies is rapidly advancing and the important role of miniaturised diagnostics is becoming more evident in the healthcare system, with particular importance in near patient testing (NPT) and point of care (POC) settings. Microfluidic technologies present innovative solutions to diagnostic and clinical challenges which have the knock-on effect of improving health care and quality of life. In this review, both advanced microfluidic devices (R&D) and commercially available devices for the diagnosis and monitoring of haemostasis-related disorders and antithrombotic therapies, respectively, are discussed. Innovative design specifications, fabrication techniques, and modes of detection in addition to the materials used in developing micro-channels are reviewed in the context of application to the field of haemostasis.
止血障碍在治疗和后续管理方面既复杂又昂贵。作为全球主要的死亡原因，人们越来越致力于改善止血障碍的诊断和预防。微流控和片上实验室（LOC）技术领域正在迅速发展，微型诊断在医疗保健系统中的重要作用变得越来越明显，特别是在床边检测（NPT）和即时护理（POC）环境中。微流控技术为诊断和临床挑战提供了创新的解决方案，这些解决方案对改善医疗保健和生活质量具有连锁反应。在这篇综述中，分别讨论了用于诊断和监测与止血相关的疾病以及抗血栓治疗的先进微流控设备（研发）和商业上可用的设备。创新性的设计规格、制造技术和检测模式，以及用于开发微通道的材料，都在止血领域的应用背景下进行了回顾。
