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骨髓增生异常综合征发病机制中的慢性免疫反应失调。

Chronic immune response dysregulation in MDS pathogenesis.

机构信息

Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and.

Department of Cancer Biology, University of Cincinnati, Cincinnati, OH.

出版信息

Blood. 2018 Oct 11;132(15):1553-1560. doi: 10.1182/blood-2018-03-784116. Epub 2018 Aug 13.

DOI:10.1182/blood-2018-03-784116
PMID:30104218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6182269/
Abstract

Chronic innate immune signaling in hematopoietic cells is widely described in myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly via pattern recognition receptors, increases the risk of developing MDS. An inflammatory component to MDS has been reported for many years, but only recently has evidence supported a more direct role of chronic innate immune signaling and associated inflammatory pathways in the pathogenesis of MDS. Here we review recent findings and discuss relevant questions related to chronic immune response dysregulation in MDS.

摘要

造血细胞中的慢性固有免疫信号在骨髓增生异常综合征（MDS）中被广泛描述，固有免疫途径的激活，主要通过模式识别受体，增加了 MDS 的发病风险。MDS 的炎症成分已经报道了很多年，但直到最近，证据才支持慢性固有免疫信号和相关炎症途径在 MDS 发病机制中的更直接作用。在这里，我们回顾了最近的发现，并讨论了与 MDS 中慢性免疫反应失调相关的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29e2/6182269/715c947efbee/blood784116absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29e2/6182269/715c947efbee/blood784116absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29e2/6182269/715c947efbee/blood784116absf1.jpg

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