Department of Emergency Medicine, Ajou University School of Medicine, Suwon 16499, Korea.
Int J Mol Sci. 2018 Aug 13;19(8):2381. doi: 10.3390/ijms19082381.
Carbon monoxide (CO) is being increasingly recognized as a potential therapeutic with important signaling functions in various diseases. Carbon monoxide-releasing molecules (CORMs) show anti-apoptotic, anti-inflammatory, and anti-oxidant effects on the tissues of organisms, thus contributing to tissue homeostasis. An increase in reactive oxygen species production from the mitochondria after exposure to CO is also considered one of the underlying mechanisms of cardioprotection, although mitochondrial inhibition is the main toxic mechanism of CO poisoning. This review highlights the mechanism of the biological effects of CO and its potential application as a therapeutic in clinical settings, including in cardiovascular diseases. This review also discusses the obstacles and limitations of using exogenous CO or CORMs as a therapeutic option, with respect to acute CO poisoning.
一氧化碳（CO）作为一种潜在的治疗药物，在各种疾病中具有重要的信号功能，正越来越受到人们的重视。一氧化碳释放分子（CORMs）对机体组织具有抗凋亡、抗炎和抗氧化作用，从而有助于组织的内稳态。CO 暴露后线粒体中活性氧的产生增加也被认为是心肌保护的潜在机制之一，尽管线粒体抑制是 CO 中毒的主要毒性机制。本综述重点介绍了 CO 的生物学效应的机制及其在临床环境中作为治疗药物的潜在应用，包括在心血管疾病中的应用。本文还讨论了在急性 CO 中毒的情况下，将外源性 CO 或 CORMs 用作治疗选择所面临的障碍和限制。
