Center for Medical Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Nutrients. 2018 Aug 13;10(8):1083. doi: 10.3390/nu10081083.
Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participants-healthy subjects or patients with known or suspected CAD. Comparisons-recent caffeine intake versus no caffeine intake. Outcomes-measurements of functional myocardial perfusion. Study design-observational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories.
咖啡因是世界范围内最广泛使用的兴奋剂之一。它是一种公认的腺苷拮抗剂，也是血管扩张性心肌灌注期间功能性测量出现假阴性的潜在原因。本系统评价的目的是总结有关咖啡因摄入对疑似冠心病患者心肌灌注功能测量的影响的证据。使用预定义的电子搜索策略在 Pubmed、Web of Science 和 Embase 中进行了搜索。参与者-健康受试者或已知或疑似 CAD 患者。比较-近期咖啡因摄入与无咖啡因摄入。结果-功能性心肌灌注的测量。研究设计-观察性。有 14 项研究被认为符合本系统评价的标准。研究设计存在很大的变异性，包括不同的成像方式、血管扩张剂、咖啡因的血清浓度和主要的结果测量。现有数据表明，近期咖啡因摄入对腺苷和双嘧达莫诱导的充血时心脏灌注测量有显著影响。这些影响有可能通过重新分类到不同的风险类别来影响临床决策。
