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癌症患者中PHH3表达预后价值的汇总分析。

Pooling analysis on prognostic value of PHH3 expression in cancer patients.

作者信息

Hao Qian, Dai Cong, Deng Yujiao, Xu Peng, Tian Tian, Lin Shuai, Wang Meng, Liu Kang, Song Dingli, Wu Ying, Guo Yan, Dai Zhijun

机构信息

Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China,

School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China,

出版信息

Cancer Manag Res. 2018 Jul 30;10:2279-2288. doi: 10.2147/CMAR.S167569. eCollection 2018.

DOI:10.2147/CMAR.S167569
PMID:30104898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6071623/
Abstract

BACKGROUND

Various studies have evaluated the significance of phosphohistone-H3 (PHH3) expression in cancer patients, but controversy over its reliability remains. We conducted a meta-analysis to summarize the prognostic relevance of PHH3 expression in cancer patients.

PATIENTS AND METHODS

Nineteen studies, including 4803 patients, were identified by searching PubMed, Web of Science, Embase, and Cochrane Library. The correlation of PHH3 expression level with overall survival (OS), disease-free survival, and recurrence-free survival was analyzed.

RESULTS

Overall, the results suggest that high expression of PHH3 can predict a poor OS (HR=2.66, 95% CI=1.74-4.08, <0.001), disease-free survival (HR=3.40, 95% CI=1.47-7.87, =0.004), and recurrence-free survival (HR=2.80, 95% CI=1.61-4.85, <0.001) in cancer patients. The subgroup analysis showed that highly expressed PHH3 was significantly related to breast cancer (HR=5.66, 95% CI=2.72-11.78, <0.001) and urogenital tumors (HR=3.01, 95% CI=1.78-5.09, <0.001). Furthermore, no significant difference was found between Asian (HR=1.98, 95% CI=1.08-3.63, =0.026) and Caucasian populations (HR=3.01, 95% CI=1.87-4.85, <0.001) regarding OS and PHH3 expression.

CONCLUSION

This meta-analysis indicates that high expression of PHH3 may serve as a biomarker for poor prognosis in patients with cancer.

摘要

背景

多项研究评估了磷酸化组蛋白H3（PHH3）表达在癌症患者中的意义，但其可靠性仍存在争议。我们进行了一项荟萃分析，以总结PHH3表达在癌症患者中的预后相关性。

患者与方法

通过检索PubMed、科学网、Embase和考克兰图书馆，确定了19项研究，共4803例患者。分析了PHH3表达水平与总生存期（OS）、无病生存期和无复发生存期的相关性。

结果

总体而言，结果表明，PHH3高表达可预测癌症患者较差的总生存期（HR=2.66，95%CI=1.74-4.08，P<0.001）、无病生存期（HR=3.40，95%CI=1.47-7.87，P=0.004）和无复发生存期（HR=2.80，95%CI=1.61-4.85，P<0.001）。亚组分析显示，PHH3高表达与乳腺癌（HR=5.66，95%CI=2.72-11.78，P<0.001）和泌尿生殖系统肿瘤（HR=3.01，95%CI=1.78-5.09，P<0.001）显著相关。此外，在总生存期和PHH3表达方面，亚洲人群（HR=1.98，95%CI=1.08-3.63，P=0.026）和白种人群（HR=3.01，95%CI=1.87-4.85，P<0.001）之间未发现显著差异。

结论

这项荟萃分析表明，PHH3高表达可能作为癌症患者预后不良的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/5522366d8379/cmar-10-2279Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/5c61cc6311ae/cmar-10-2279Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/4f1a61201100/cmar-10-2279Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/55dee693d038/cmar-10-2279Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/189a956ddbac/cmar-10-2279Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/7a79c9e8686e/cmar-10-2279Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/5522366d8379/cmar-10-2279Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/5c61cc6311ae/cmar-10-2279Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/4f1a61201100/cmar-10-2279Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/55dee693d038/cmar-10-2279Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/189a956ddbac/cmar-10-2279Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/7a79c9e8686e/cmar-10-2279Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f3/6071623/5522366d8379/cmar-10-2279Fig6.jpg

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