Healey Kevin, Lawlor Chris, Knox Malcolm R, Chambers Michael, Lamb Jane, Groves Peter
International Animal Health Products Pty Ltd, PO Box 6199 Blacktown, NSW 2148, Australia.
CSIRO F.D. McMaster Laboratory, Locked Bag 1 Armidale NSW 2350, Australia.
Vet Parasitol. 2018 Jul 15;258:124-132. doi: 10.1016/j.vetpar.2018.06.017. Epub 2018 Jun 24.
A series of placebo-controlled trials were conducted in horses, cattle and goats in different seasons and bioclimatic regions of New South Wales and Queensland, Australia, to evaluate the ability of BioWorma®, a feed supplement containing the spores of Duddingtonia flagrans IAH 1297, to reduce the larval development of parasitic gastrointestinal nematodes (GIN) and their subsequent migration from faeces onto the surrounding pasture. In each trial, faeces were collected from animals harbouring a burden of nematode parasites following a period of supplementation with a placebo and again after supplementation with BioWorma. The faeces were manually placed onto pasture plots at one or two distinct geographical sites and the effect of treatment was determined by subsequent monitoring the numbers of parasitic larvae on the pasture surrounding the faecal pats at two weekly intervals over an eight week period. The results for these studies showed that administration of BioWorma at a minimum daily dose of 3 × 10 spores/kg bodyweight reduced parasite larvae in the pasture surrounding the faeces by 53-99 % over an eight week post treatment period in horses, cattle and goats in a range of bioclimatic zones and in different seasons. Overall, the studies with BioWorma show substantial reductions in GIN infectivity of pasture surrounding faeces of treated horses, cattle and goats (P < 0.05). Results indicate that the use of BioWorma in these host species would lead to decreased levels of GIN infection in animals grazing pasture when this product is used and would provide an alternative means of controlling parasitic nematodes.
在澳大利亚新南威尔士州和昆士兰州不同季节和生物气候区域的马、牛和山羊身上进行了一系列安慰剂对照试验，以评估BioWorma®（一种含有杜氏节丛孢菌IAH 1297孢子的饲料添加剂）减少寄生性胃肠线虫（GIN）幼虫发育及其随后从粪便迁移到周围牧场的能力。在每项试验中，在动物用安慰剂补充一段时间后以及用BioWorma补充后，从携带线虫寄生虫的动物身上收集粪便。将粪便手动放置在一个或两个不同地理位置的牧场上，通过在八周内每隔两周监测粪便堆周围牧场上寄生幼虫的数量来确定治疗效果。这些研究的结果表明，在一系列生物气候区和不同季节的马、牛和山羊中，在治疗后的八周内，以最低每日剂量3×10个孢子/千克体重施用BioWorma可使粪便周围牧场中的寄生虫幼虫减少53%至99%。总体而言，对BioWorma的研究表明，经处理的马、牛和山羊粪便周围牧场的GIN感染性大幅降低（P<0.05）。结果表明，在这些宿主物种中使用BioWorma将导致使用该产品时放牧牧场的动物体内GIN感染水平降低，并将提供一种控制寄生线虫的替代方法。
