Hurst Carolyn, Rosenberg Jonathan, Knowles Margaret
Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 353 E 68(th) Street, New York, NY 10065, USA.
Cancer Cell. 2018 Aug 13;34(2):350-350.e1. doi: 10.1016/j.ccell.2018.07.013.
Bladder cancers, the majority of which are urothelial carcinoma, are the most common urinary tract cancers. There are two major disease types, muscle-invasive and non-muscle-invasive, with distinct pathogenesis pathways, molecular features, and clinical outcomes. Recent genomic and transcriptomic data have significantly improved tumor sub-classification and prognostication for both patient groups and are informing improved approaches to treatment of muscle-invasive disease. To view this SnapShot, open or download the PDF.
膀胱癌是最常见的泌尿系统癌症,其中大多数为尿路上皮癌。膀胱癌主要有两种类型,即肌肉浸润性和非肌肉浸润性,它们具有不同的发病机制途径、分子特征和临床结果。最近的基因组和转录组数据显著改善了这两类患者的肿瘤亚分类和预后评估,并为改进肌肉浸润性疾病的治疗方法提供了依据。要查看此快照,请打开或下载PDF文件。