Park Yun-A, Lee Sung Ryul, Lee Jin Woo, Koo Hyun Jung, Jang Seon-A, Yun Seung-Won, Kim Hyun Ju, Woo Jeong Suk, Park Myung Rye, Kang Se Chan, Kim Youn Kyu, Sohn Eun-Hwa
Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Republic of Korea.
Department of Convergence Biomedical Science, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Busan 47392, Republic of Korea.
J Microbiol Biotechnol. 2018 Aug 28;28(8):1391-1400. doi: 10.4014/jmb.1805.05065.
root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of root fermented by (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; 30 mJ/cm) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate at the basal condition. FAT also favored the maintenance and/or improvement of extracellular matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1 synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to play a role in the attenuation of inflammatory responses caused by UVB irradiation via upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.
在韩国，根历来被用作传统药物。先前的研究已经确定了由（某种物质）发酵的根提取物的抗黑素生成作用。本研究调查了发酵根提取物（FAT）对HaCaT（人角质形成细胞）或Hs68（人包皮成纤维细胞）皮肤细胞紫外线B照射（UVB；30 mJ/cm）的保护作用。FAT处理能够在基础条件下刺激伤口愈合率。FAT还通过以下方式有利于维持和/或改善由UVB照射引起的细胞外基质损伤：1）上调I型前胶原的合成和分泌；2）抑制MMP-1和弹性蛋白酶的表达。FAT能够通过上调光保护血红素加氧酶-1和抑制促炎环氧化酶-2的表达，在减轻UVB照射引起的炎症反应中发挥作用。在进一步验证FAT的抗光老化潜力后，它可作为抗衰老和抗皱化妆品的有效成分。
