Lahav-Baratz S, Blais I, Koifman M, Ishai D, Wiener-Megnazi Z, Peer G, Dirnfeld M
Obs/Gyn Department IVF Unit, Lady Davis Carmel Medical Center, Haifa, Israel.
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Case Rep Obstet Gynecol. 2018 Jul 19;2018:2152918. doi: 10.1155/2018/2152918. eCollection 2018.
We report a live birth from a heavily fragmented embryo which continued cleavage to a fully expanded blastocyst. A 32-year-old patient underwent 2 IVF cycles without achieving pregnancy. In the first cycle, 2 embryos with fragmentation were transferred; in the second, all embryos were fragmented and no embryo transfer was performed. In a third cycle, 12 oocytes were retrieved and 11 of them were fertilized. On day 2, all 11 embryos started to unwind to fragments. By careful annotation, using the time-lapse EmbryoScope, we observed that one embryo continued division as expected, discarding all fragments aside. On day 5, this embryo showed promising annotation according to our lab model. The embryo was transferred into the uterus and resulted in the birth of a healthy baby at term. To our knowledge, this is the first case report assisted by EmbryoScope where a healthy baby was delivered from a fragmented embryo.
我们报告了一例来自严重碎片化胚胎的活产病例，该胚胎持续分裂直至完全扩张的囊胚。一名32岁的患者接受了2次体外受精周期，但均未成功怀孕。在第一个周期中，移植了2个有碎片化的胚胎；在第二个周期中，所有胚胎均碎片化，未进行胚胎移植。在第三个周期中，获取了12个卵母细胞，其中11个受精。在第2天，所有11个胚胎开始解旋成碎片。通过使用延时胚胎观察仪进行仔细记录，我们观察到一个胚胎按预期继续分裂，将所有碎片丢弃一旁。在第5天，根据我们实验室的模型，这个胚胎显示出良好的记录结果。该胚胎被移植到子宫内，足月分娩出一个健康的婴儿。据我们所知，这是首例在胚胎观察仪辅助下，由碎片化胚胎分娩出健康婴儿的病例报告。
