Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia.
Department of Medicine, Allied Research Society LLC, Baranquilla.
J Infect Dis. 2019 Jan 1;219(1):26-30. doi: 10.1093/infdis/jiy466.
The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
中和抗体在寨卡病毒引起的格林-巴利综合征（GBS）中的作用尚未得到研究。我们使用 2016 年哥伦比亚寨卡疫情期间的血清进行了病例对照研究，以确定针对寨卡病毒（ZIKV）和登革热病毒血清型 2（DENV2）的中和抗体活性。我们观察到与未感染对照相比，感染寨卡病毒的个体对登革热病毒 2 型的中和抗体滴度升高，并且与非 GBS 寨卡病毒感染对照组相比，在诊断为 GBS 的寨卡病毒感染患者中，对 ZIKV 和 DENV2 的滴度更高。这些数据表明，在寨卡病毒感染期间，针对 DENV 和 ZIKV 的高中和抗体滴度与 GBS 相关。
