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对免疫缺陷患者淋巴细胞免疫球蛋白合成与分泌的调节作用。

Modulatory effects on immunoglobulin synthesis and secretion by lymphocytes from immunodeficient patients.

作者信息

Schwartz S A, Choi Y S, Shou L, Good R A

出版信息

J Clin Invest. 1977 Jun;59(6):1176-87. doi: 10.1172/JCI108742.

DOI:10.1172/JCI108742

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC372331/

Abstract

Incubation of peripheral lymphocytes (PBL) from normal donors with pokeweek mitogen (PWM) induced terminal differentiation by B lymphocytes to immunoglobulin (Ig) synthesizing and secreting plasma cells. B cells from hypogammaglobulinemic patients with different primary immunodeficiencies failed to undergo functional differentiation after similar treatment with PWM. Co-cultures of BL from normal donors and hypogammaglobulinemic patients often resulted in deviations, both positive and negative, from expected levels of PWM-stimulated intracellular Ig biosynthesis. Suppression of B-cell differentiation was manifested by PBL from patients with several different primary immunodeficiencies, including infantile sex-linked agammaglobulinemia. Immunoregulatory activities were noted to vary with the normal donor used in co-culture experiments and with time. Cell populations that were active in influencing B-cell differentiation to functional plasma cells did not have an appreciable modulatory effect on T-lymphocyte responses to mitogens. These observations may provide a functional subclassifications for immunoregulatory cells in man.

摘要

用美洲商陆丝裂原（PWM）培养正常供体的外周淋巴细胞（PBL）可诱导B淋巴细胞终末分化为合成和分泌免疫球蛋白（Ig）的浆细胞。患有不同原发性免疫缺陷的低丙种球蛋白血症患者的B细胞在经类似的PWM处理后未能发生功能分化。正常供体和低丙种球蛋白血症患者的B淋巴细胞共培养常常导致PWM刺激的细胞内Ig生物合成水平出现高于或低于预期的偏差。包括婴儿性连锁无丙种球蛋白血症在内的几种不同原发性免疫缺陷患者的PBL表现出对B细胞分化的抑制作用。免疫调节活性被发现会因共培养实验中所用的正常供体以及时间的不同而有所变化。对B细胞分化为功能性浆细胞有积极影响的细胞群体对T淋巴细胞对丝裂原的反应没有明显的调节作用。这些观察结果可能为人的免疫调节细胞提供一种功能亚分类。