Blaese R M, Weiden P L, Koski I, Dooley N
J Exp Med. 1974 Oct 1;140(4):1097-1101. doi: 10.1084/jem.140.4.1097.
Agammaglobulinemia induced in chickens by surgical bursectomy and irradiation at hatching is transmissible at 4 mo of age to sublethally irradiated normal chickens by bone marrow transplantation. The immunodeficiency which develops in the recipients persists for life and is characterized by inability to produce antibody and by progressive loss of detectable serum IgM and IgG.
通过在孵化时进行手术切除法氏囊和照射诱导鸡产生的无丙种球蛋白血症,在4月龄时通过骨髓移植可传播给经亚致死剂量照射的正常鸡。受体中出现的免疫缺陷会持续终生,其特征是无法产生抗体以及可检测到的血清IgM和IgG逐渐丧失。