人类T淋巴细胞亚群。十五。具有IgA受体的T淋巴细胞（Tα），一种独特的T淋巴细胞亚群。对原发性免疫缺陷病患者的研究。
Subpopulations of human T lymphocytes. XV. T lymphocytes with receptors for IgA (T alpha), a distinct subpopulation of T lymphocytes. Studies in patients with primary immunodeficiency disorders.
作者信息
Gupta S, Good R A
出版信息
Clin Exp Immunol. 1980 Aug;41(2):363-71.
A receptor for IgA was observed on a subset of T cells (T alpha) that is distinct from other T lymphocyte subsets, T mu or T gamma cells. IgA receptor on T alpha cells is blocked by IgA from human serum through its cytophilic attachment. Neither T mu nor T gamma cells, following an in vitro interaction with insoluble immune complexes during the process of purification and further incubation at 37 degrees C, changed their phenotypes to T alpha cells. However, some T gamma cells demonstrated transition to T mu cells. The numbers and proportion of T alpha cells in patients with selective IgA deficiency were either normal, increased or decreased. The significance of T alpha cell analysis in thirty-one patients with primary immunodeficiency disorders including those with selective IgA deficiency is discussed.
在一类与其他T淋巴细胞亚群（Tμ或Tγ细胞）不同的T细胞亚群（Tα）上观察到了IgA受体。Tα细胞上的IgA受体可被人血清中的IgA通过其嗜细胞性附着所阻断。在纯化过程中，Tμ细胞和Tγ细胞在体外与不溶性免疫复合物相互作用并于37℃进一步孵育后，均未转变为Tα细胞表型。然而，一些Tγ细胞表现出向Tμ细胞的转变。选择性IgA缺乏症患者中Tα细胞的数量和比例可正常、增加或减少。本文讨论了对31例原发性免疫缺陷疾病患者（包括选择性IgA缺乏症患者）进行Tα细胞分析的意义。
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