Institut d'Investigacions Biomèdiques August Pi I Sunyer and Centro de Investigación Biomedica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain; Department of Cardiovascular and Metabolic Diseases, Istituto Ricerca Cura Carattere Scientifico Multimedica, Sesto San Giovanni, Italy.
Institute of Clinical Research, University of Montpellier, Montpellier, France.
Lancet Diabetes Endocrinol. 2019 Mar;7(3):221-230. doi: 10.1016/S2213-8587(18)30136-0. Epub 2018 Aug 13.
Glycaemic variability is an integral component of glucose homoeostasis. Although it has not yet been definitively confirmed as an independent risk factor for diabetes complications, glycaemic variability can represent the presence of excess glycaemic excursions and, consequently, the risk of hyperglycaemia or hypoglycaemia. Glycaemic variability is currently defined by a large and increasing number of metrics, representing either short-term (within-day and between-day variability) or long-term glycaemic variability, which is usually based on serial measurements of HbA or other measures of glycaemia over a longer period of time. In this Review, we discuss recent evidence examining the association between glycaemic variability and diabetes-related complications, as well as non-pharmacological and pharmacological strategies currently available to address this challenging aspect of diabetes management.
血糖变异性是血糖稳态的一个组成部分。尽管它尚未被明确确认为糖尿病并发症的独立危险因素，但血糖变异性可以代表存在过多的血糖波动，因此存在发生高血糖或低血糖的风险。目前，血糖变异性由大量且不断增加的指标定义，这些指标代表短期（日内和日间变异性）或长期血糖变异性，通常基于 HbA 或其他血糖测量值在较长时间内的连续测量。在这篇综述中，我们讨论了最近的证据，这些证据检查了血糖变异性与糖尿病相关并发症之间的关联，以及目前可用于解决糖尿病管理这一具有挑战性方面的非药物和药物策略。
