Izadi Vajihe, Esmaillzadeh Ahmad, Hashemipour Mahin, Surkan Pamela J, Azadbakht Leila, Kelishadi Roya
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
J Cardiovasc Thorac Res. 2018;10(2):95-103. doi: 10.15171/jcvtr.2018.15. Epub 2018 Jun 27.
Limited information exists regarding the effects of high protein (HP) diets on cardiovascular disease (CVD) risk factors among overweight and obese children. Our aim was to determine the effects of an HP diet on anthropometric indexes and CVD risk factors among overweight and obese children. In a parallel randomized controlled trial, we recruited 50 overweight and obese children, aged 6-11 years, for a 10 week HP or control diet (protein, carbohydrate, fat: 25%, 45%, 30% in the HP diet vs. 15%, 55%, 30% in the control diet, respectively). Fasting blood glucose (FBG) serum insulin levels, lipid profiles, systolic and diastolic blood pressure (SBP and DBP), and anthropometric measurements were assessed using standard guidelines. 86% of children completed the trial. Percent changes (PC) for anthropometric and biochemical variables were not significantly different between the two groups. The PC of serum triglyceride (TG) level was significantly decreased in the HP group compared to in the control group (PC: -10.16±4.30% vs.12.11±7.80%; P = 0.01) in the crude model, but not in the adjusted model. For other variables, we did not find any significant differences between the HP group and the controls. In the present study, we did not find any significant effect of adherence to an HP diet in improving anthropometric measurements or other CVD risk factors among obese and overweight children.
关于高蛋白（HP）饮食对超重和肥胖儿童心血管疾病（CVD）风险因素的影响，现有信息有限。我们的目的是确定HP饮食对超重和肥胖儿童人体测量指标和CVD风险因素的影响。在一项平行随机对照试验中，我们招募了50名6至11岁的超重和肥胖儿童，进行为期10周的HP饮食或对照饮食（蛋白质、碳水化合物、脂肪：HP饮食中分别为25%、45%、30%，对照饮食中分别为15%、55%、30%）。使用标准指南评估空腹血糖（FBG）、血清胰岛素水平、血脂谱、收缩压和舒张压（SBP和DBP）以及人体测量指标。86%的儿童完成了试验。两组之间人体测量和生化变量的百分比变化（PC）没有显著差异。在粗略模型中，HP组血清甘油三酯（TG）水平的PC与对照组相比显著降低（PC：-10.16±4.30%对12.11±7.80%；P = 0.01），但在调整模型中没有。对于其他变量，我们在HP组和对照组之间没有发现任何显著差异。在本研究中，我们没有发现坚持HP饮食对改善肥胖和超重儿童的人体测量指标或其他CVD风险因素有任何显著影响。
