Yılmaz Sevil Karahan, Eskici Günay, Mertoǧlu Cuma, Ayaz Aylin
Department of Nutrition and Dietetics, Faculty of Health Sciences, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Department of Coaching, Faculty of Sport Science, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
J Res Med Sci. 2021 May 27;26:28. doi: 10.4103/jrms.JRMS_611_20. eCollection 2021.
Reducing and maintaining body weight has become more important than ever as obesity is becoming increasingly common worldwide. This study was aimed to investigate the effects of diets with different protein contents administered to obese women on anthropometric measurements, inflammatory markers, and cardiometabolic risk factors.
This randomized controlled trial was conducted with sixty volunteering obese women aged between 20 and 45 years. The subjects were divided into two groups in equal numbers. The high-protein (HP) group ( = 30) was administered an iso-caloric HP diet (25% protein, 30% fat, and 45% carbohydrate), and the control group ( = 30) an isocaloric low-protein diet (15% protein, 30% fat, and 55% carbohydrate), and both groups were followed up for 8 weeks. The subjects' descriptive data, anthropometric measurements, homeostatic model assessment-insulin resistance (HOMA-IR), lipid profiles, and high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) levels were analyzed.
There was no significant difference at baseline (except for low-density lipoprotein cholesterol [LDL-C]), and end-of-study (except for IL-6, systolic blood pressure [SBP], and diastolic blood pressure) values of parameters between the two groups; after adjusted for baseline measurements, a significant difference was observed between the groups for body weight, body mass index, waist circumference, HOMA-IR, LDL-C, hs-CRP, TNF-α, IL-6, and SBP ( = 0.004, = 0.001, = 0.003, = 0.029, = 0.004, = 0.016, = 0.004, = 0.010, and = 0.000, respectively) and were greater in the HP group than in the control group ( < 0.05).
The HP diet was effective on improvement in HOMA-IR, SBP, LDL-C, hs-CRP, TNF-α, IL-6, and resulted in body weight loss.
随着肥胖在全球范围内日益普遍，减轻并维持体重变得比以往任何时候都更加重要。本研究旨在调查给予肥胖女性不同蛋白质含量的饮食对人体测量指标、炎症标志物和心脏代谢危险因素的影响。
本随机对照试验对60名年龄在20至45岁之间的肥胖女性志愿者进行。受试者被平均分为两组。高蛋白（HP）组（n = 30）给予等热量的高蛋白饮食（25%蛋白质、30%脂肪和45%碳水化合物），对照组（n = 30）给予等热量的低蛋白饮食（15%蛋白质、30%脂肪和55%碳水化合物），两组均随访8周。分析受试者的描述性数据、人体测量指标、稳态模型评估胰岛素抵抗（HOMA-IR）、血脂谱以及高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平。
两组之间在基线（除低密度脂蛋白胆固醇[LDL-C]外）和研究结束时（除IL-6、收缩压[SBP]和舒张压外）参数值无显著差异；在对基线测量值进行调整后，两组之间在体重、体重指数、腰围、HOMA-IR、LDL-C、hs-CRP、TNF-α、IL-6和SBP方面观察到显著差异（分别为P = 0.004、P = 0.001、P = 0.003、P = 0.029、P = 0.004、P = 0.016、P = 0.004、P = 0.010和P = 0.000），且HP组高于对照组（P < 0.05）。
高蛋白饮食对改善HOMA-IR、SBP、LDL-C、hs-CRP、TNF-α、IL-6有效，并导致体重减轻。
