梅毒全球流行病学最新情况
An Update on the Global Epidemiology of Syphilis.
作者信息
Kojima Noah, Klausner Jeffrey D
机构信息
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90095.
Fielding School of Public Health, University of California Los Angeles, Los Angeles, 90024.
出版信息
Curr Epidemiol Rep. 2018 Mar;5(1):24-38. doi: 10.1007/s40471-018-0138-z. Epub 2018 Feb 19.
Abstract
PURPOSE OF REVIEW
Syphilis continues to cause morbidity and mortality worldwide. While syphilis infection is easily identifiable and treatable, rates of syphilis infection continue to increase among select populations in high-income countries and remain at endemic levels in low- and middle-income counties.
RECENT FINDINGS
World Health Organization recommended strategies have led to the dual elimination of mother-to-child transmission of syphilis and HIV in several countries, however outbreaks among select populations need to be adequately addressed.
SUMMARY
Continued vigilance and investment is needed to address syphilis worldwide. The epidemiology of syphilis differs in high-income and low- and middle-income counties.
摘要
综述目的
梅毒在全球范围内持续导致发病和死亡。虽然梅毒感染易于识别和治疗，但在高收入国家的特定人群中，梅毒感染率持续上升，在低收入和中等收入国家仍处于流行水平。
最新发现
世界卫生组织推荐的策略已在多个国家实现了梅毒和艾滋病毒母婴传播的双重消除，然而，特定人群中的疫情仍需得到充分应对。
总结
应对全球梅毒问题需要持续保持警惕并投入资源。梅毒的流行病学在高收入国家与低收入和中等收入国家有所不同。
相似文献
1
An Update on the Global Epidemiology of Syphilis.梅毒全球流行病学最新情况
Curr Epidemiol Rep. 2018 Mar;5(1):24-38. doi: 10.1007/s40471-018-0138-z. Epub 2018 Feb 19.
3
Syphilis.梅毒。
Nat Rev Dis Primers. 2017 Oct 12;3:17073. doi: 10.1038/nrdp.2017.73.
4
Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol.梅毒免疫学和苍白密螺旋体亚种生物学研究以改善临床管理和设计广泛保护性疫苗：研究方案。
BMC Infect Dis. 2020 Jun 23;20(1):444. doi: 10.1186/s12879-020-05141-0.
5
Syphilis Vaccine Development: Requirements, Challenges, and Opportunities.梅毒疫苗研发：需求、挑战与机遇。
Sex Transm Dis. 2018 Sep;45(9S Suppl 1):S17-S19. doi: 10.1097/OLQ.0000000000000831.
6
subsp. with an Artificially Impaired TprK Antigenic Variation System is Attenuated in the Rabbit Model of Syphilis.在梅毒兔模型中，具有人工受损TprK抗原变异系统的亚种减毒。
bioRxiv. 2023 Feb 23:2023.01.18.524629. doi: 10.1101/2023.01.18.524629.
8
Congenital syphilis in Switzerland: a marker of inequality? A mini-review.瑞士先天性梅毒：不平等的标志？一篇迷你综述。
Front Public Health. 2023 Sep 14;11:1265725. doi: 10.3389/fpubh.2023.1265725. eCollection 2023.
9
Sexual transmission of hepatitis B in Mwanza, Tanzania.坦桑尼亚姆万扎地区乙型肝炎的性传播
Sex Transm Dis. 1997 Mar;24(3):121-6. doi: 10.1097/00007435-199703000-00001.
10
Syphilis.梅毒。
Lancet. 2017 Apr 15;389(10078):1550-1557. doi: 10.1016/S0140-6736(16)32411-4. Epub 2016 Dec 18.
引用本文的文献
1
Oral lesions as the presenting manifestation of syphilis: A case series of an alarming trend in Kuwait.以口腔病变为梅毒首发表现：科威特一系列令人担忧趋势的病例报道
IDCases. 2025 Aug 5;41:e02338. doi: 10.1016/j.idcr.2025.e02338. eCollection 2025.
2
Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of outer membrane proteins.BamA和FadL候选疫苗原的序列变异性表明外膜蛋白的进化路径不同。
J Bacteriol. 2025 Aug 21;207(8):e0015925. doi: 10.1128/jb.00159-25. Epub 2025 Jul 14.
3
Canadian Public Health Laboratory Network National Syphilis In-Laboratory Serological Testing Recommendations.加拿大公共卫生实验室网络梅毒实验室血清学检测国家建议
J Assoc Med Microbiol Infect Dis Can. 2025 Apr 4;10(2):112-126. doi: 10.3138/jammi-2024-0027. eCollection 2025 Jun.
4
Epidemiological characteristics and socioeconomic factors of sexually transmitted infections in China during 2002-2021.2002年至2021年中国性传播感染的流行病学特征及社会经济因素
BMC Public Health. 2025 Jul 2;25(1):2194. doi: 10.1186/s12889-025-22515-8.
5
Proteinuria and Palmar Clues: Rediscovering the Renal Face of Syphilis.蛋白尿与手掌线索：重新认识梅毒的肾脏表现
Cureus. 2025 May 29;17(5):e85031. doi: 10.7759/cureus.85031. eCollection 2025 May.
6
Epidemiological spectrum of infectious uveitis in the Asia-Pacific.亚太地区感染性葡萄膜炎的流行病学谱
Taiwan J Ophthalmol. 2025 Jun 10;15(2):157-181. doi: 10.4103/tjo.TJO-D-25-00052. eCollection 2025 Apr-Jun.
7
Prevalence and management of syphilis at primary healthcare level in the Free State, South Africa.南非自由邦初级卫生保健层面梅毒的患病率及管理情况
S Afr J Infect Dis. 2025 May 31;40(1):724. doi: 10.4102/sajid.v40i1.724. eCollection 2025.
8
Seroprevalence of syphilis and associated factors among pregnant women who attended antenatal care follow-up at public hospitals in Bahir Dar city, north-west Ethiopia: a cross-sectional study.埃塞俄比亚西北部巴赫达尔市公立医院接受产前保健随访的孕妇梅毒血清流行率及相关因素：一项横断面研究。
BMJ Public Health. 2025 May 14;3(1):e002017. doi: 10.1136/bmjph-2024-002017. eCollection 2025.
9
Factors influencing adult and adolescent completion of treatment for late syphilis: a mixed methods systematic review.影响成人及青少年晚期梅毒治疗完成情况的因素：一项混合方法的系统评价
Bull World Health Organ. 2025 May 1;103(5):316-327E. doi: 10.2471/BLT.24.291684. Epub 2025 Apr 1.
10
Dual Immunization with Lipoprotein Tp0663 and Flagellin FlaB3 Offers Augmented Protection against in Mice.脂蛋白Tp0663和鞭毛蛋白FlaB3双重免疫可增强小鼠对……的保护作用。（原文中“against”后面缺少具体内容）
ACS Omega. 2025 Apr 16;10(16):16853-16862. doi: 10.1021/acsomega.5c00495. eCollection 2025 Apr 29.
本文引用的文献
1
Changing Epidemic of HIV and Syphilis Among Resident and Migrant Men Who Have Sex with Men in Jiangsu, China.江苏省男男性行为者中本地和流动人口艾滋病毒和梅毒感染的流行变化。
Sci Rep. 2017 Aug 25;7(1):9478. doi: 10.1038/s41598-017-08671-x.
2
The prevalence and incidence of active syphilis in women in Morocco, 1995-2016: Model-based estimation and implications for STI surveillance.1995 - 2016年摩洛哥女性活动性梅毒的患病率和发病率：基于模型的估计及其对性传播感染监测的意义
PLoS One. 2017 Aug 24;12(8):e0181498. doi: 10.1371/journal.pone.0181498. eCollection 2017.
3
Syphilis and HIV prevalence and associated factors to their co-infection, hepatitis B and hepatitis C viruses prevalence among female sex workers in Rwanda.卢旺达女性性工作者中梅毒和艾滋病毒的流行情况及其合并感染的相关因素、乙型肝炎和丙型肝炎病毒的流行情况。
BMC Infect Dis. 2017 Jul 28;17(1):525. doi: 10.1186/s12879-017-2625-0.
4
A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis.一项关于评估HIV和梅毒双床旁检测性能及操作特征的研究的系统评价和荟萃分析。
Sex Transm Infect. 2017 Dec;93(S4):S3-S15. doi: 10.1136/sextrans-2016-053069. Epub 2017 Jul 26.
5
Increased synthetic drug abuse and trends in HIV and syphilis prevalence among female drug users from 2010-2014 from Beijing, China.2010年至2014年期间中国北京女性吸毒者中合成毒品滥用增加及艾滋病毒和梅毒流行趋势。
Int J STD AIDS. 2018 Jan;29(1):30-37. doi: 10.1177/0956462417715174. Epub 2017 Jul 11.
6
Number of cases of syphilis continue to rise.梅毒病例数量持续上升。
BMJ. 2017 Jun 8;357:j2807. doi: 10.1136/bmj.j2807.
7
Prevalence and risk factors associated with sexually transmitted infections (STIs) among women of reproductive age in Swaziland.斯威士兰育龄女性中性传播感染（STIs）的患病率及相关风险因素。
Infect Agent Cancer. 2017 May 25;12:29. doi: 10.1186/s13027-017-0140-y. eCollection 2017.
8
The Evidence That Increased Syphilis Testing Controls Syphilis Is Compelling: What Is Needed to Act?梅毒检测增加可控制梅毒这一证据令人信服：采取行动需要什么？
Clin Infect Dis. 2017 Aug 1;65(3):396-397. doi: 10.1093/cid/cix329.
9
Increased Syphilis Testing of Men Who Have Sex With Men: Greater Detection of Asymptomatic Early Syphilis and Relative Reduction in Secondary Syphilis.增加男男性行为者的梅毒检测：更易发现无症状早期梅毒，二期梅毒相对减少。
Clin Infect Dis. 2017 Aug 1;65(3):389-395. doi: 10.1093/cid/cix326.
10
The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru.毕加索队列研究：秘鲁利马梅毒感染高危的男男性行为者和男变女跨性别女性队列的基线特征
BMC Infect Dis. 2017 Apr 11;17(1):255. doi: 10.1186/s12879-017-2332-x.
Zotero 插件