Department of Dermatology, Venereology and Allergology, University Medical Center, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
J Dtsch Dermatol Ges. 2018 Aug;16(8):992-999. doi: 10.1111/ddg.13601.
In his initial publication of frontal fibrosing alopecia (FFA) in 1994, Steven Kossard included six postmenopausal women. A type of cicatricial alopecia, FFA is clinically characterized by frontotemporal hairline recession and loss of eyebrows. In recent years, there has been an increasing number of case reports of FFA in both premenopausal women and men.
Review and analysis of the literature on FFA with regard to epidemiology, associated disorders, disease presentation, diagnosis and treatment.
We conducted a Pubmed database search for case reports and case series on FFA. Overall, we reviewed and analyzed data from 68 articles, including 932 patients. Apart from epidemiological data such as age, gender or ethnicity, we also assessed other aspects such as predilection sites, associated skin lesions, comorbidities, drugs and treatment response as well as the diagnostic significance of autoantibodies.
While we were able to confirm and more accurately define some of the data published in the literature, we were unable to reproduce certain assumptions that had previously been made. The high coincidence of FFA and thyroid disease we found in our analysis is particularly significant.
The present study provides the most comprehensive review to date of published cases of FFA.
1994 年，Steven Kossard 在其最初发表的额部纤维性秃发（FFA）中纳入了六名绝经后女性。FFA 是一种瘢痕性秃发，其临床特征为额颞部发际线后退和眉毛脱落。近年来，越来越多的报道称绝经前女性和男性均患有 FFA。
对 FFA 的文献进行综述和分析，内容涉及流行病学、相关疾病、疾病表现、诊断和治疗。
我们对 FFA 的病例报告和病例系列进行了 Pubmed 数据库检索。总的来说，我们对 68 篇文章中的数据进行了回顾和分析，其中包括 932 名患者。除了年龄、性别或种族等流行病学数据外，我们还评估了其他方面，如好发部位、相关皮肤病变、合并症、药物和治疗反应以及自身抗体的诊断意义。
虽然我们能够证实并更准确地定义文献中已发表的部分数据，但我们无法重现以前提出的某些假设。我们在分析中发现的 FFA 与甲状腺疾病的高吻合度尤其重要。
本研究是迄今为止对已发表的 FFA 病例进行的最全面的综述。
