Martinez-Rico Jessica Carolina, Ancer-Arellano Jesus, Martinez-Moreno Adrian, Ocampo-Garza Sonia Sofia, Ocampo-Candiani Jorge, Chavez-Alvarez Sonia
Department of Dermatology, Universidad Autonoma de Nuevo Leon, University Hospital "Dr. José Eleuterio González,", Monterrey, Mexico.
Skin Appendage Disord. 2020 Nov;6(6):362-365. doi: 10.1159/000507557. Epub 2020 Aug 26.
Frontal fibrosing alopecia (FFA) is a cicatricial alopecia characterized by hairline recession. Multiple autoimmune pathologies have been reported in patients with FFA. Despite the fact that FFA etiology remains unknown, there has been described an association with autoimmune disorders probably caused by an altered activity of cytotoxic CD8 T lymphocytes. Moreover, other autoimmune pathologies develop TH1 and TH17 response. Genetics could be responsible, in part, for the role of multiple simultaneous autoimmune disorders. Herein, we describe a case of a female patient with vitiligo, lichen sclerosus, and autoimmune hypothyroidism who developed a pruritic band-like recession of the frontal hairline. More research is needed in this area since autoimmune events in these patients may not be a mere coincidence.
额部纤维性秃发(FFA)是一种以发际线后移为特征的瘢痕性秃发。FFA患者中已报告有多种自身免疫性疾病。尽管FFA的病因尚不清楚,但已描述其与可能由细胞毒性CD8 T淋巴细胞活性改变引起的自身免疫性疾病有关。此外,其他自身免疫性疾病会产生TH1和TH17反应。遗传学可能部分导致了多种同时发生的自身免疫性疾病。在此,我们描述了一例患有白癜风、硬化性苔藓和自身免疫性甲状腺功能减退症的女性患者,其出现了额部发际线瘙痒性带状后移。由于这些患者中的自身免疫事件可能并非仅仅是巧合,因此该领域需要更多的研究。