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Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.全基因组关联研究在额部纤维性脱发中鉴定出四个易感位点,包括 HLA-B*07:02。
Nat Commun. 2019 Mar 8;10(1):1150. doi: 10.1038/s41467-019-09117-w.
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3
Frontal fibrosing alopecia - review of recent case reports and case series in PubMed.额部纤维性脱发——PubMed 中近期病例报告和病例系列的回顾。
J Dtsch Dermatol Ges. 2018 Aug;16(8):992-999. doi: 10.1111/ddg.13601.
4
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5
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Frontal fibrosing alopecia among men: A clinicopathologic study of 7 cases.男性额部纤维性脱发:7 例临床病理研究。
J Am Acad Dermatol. 2017 Oct;77(4):683-690.e2. doi: 10.1016/j.jaad.2017.05.045. Epub 2017 Jul 14.
7
Update on Frontal Fibrosing Alopecia.额部纤维性秃发的最新进展
Actas Dermosifiliogr. 2017 May;108(4):293-304. doi: 10.1016/j.ad.2016.11.012. Epub 2017 Jan 20.
8
Prevalence of hormonal and endocrine dysfunction in patients with lichen planopilaris (LPP): A retrospective data analysis of 168 patients.患有斑秃(LPP)患者的激素和内分泌功能障碍的患病率:168 例患者的回顾性数据分析。
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9
Primary cicatricial alopecia: Lymphocytic primary cicatricial alopecias, including chronic cutaneous lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, and Graham-Little syndrome.原发性瘢痕性脱发:淋巴细胞性原发性瘢痕性脱发,包括慢性皮肤型红斑狼疮、扁平苔藓样瘢痕性脱发、额部纤维性脱发和格雷厄姆-利特尔综合征。
J Am Acad Dermatol. 2016 Dec;75(6):1081-1099. doi: 10.1016/j.jaad.2014.09.058.
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Frontal Fibrosing Alopecia in Men: Presentations in 12 Cases and a Review of the Literature.男性额部纤维性秃发:12例病例报告及文献综述
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社会地位可能影响女性患者额部纤维性秃发的预后:一项观察性研究。

Social Status May Interfere in the Prognosis of Frontal Fibrosing Alopecia in Female Patients: An Observational Study.

作者信息

Papanikou Sofia, Xydeas-Kikemenis Anastasia, Nicolaidou Electra, Chatziioannou Argiro, Rigopoulos Dimitrios, Stratigos Alexandros, Chasapi Vasiliki

机构信息

Department of Dermatology and Venereology NHS, Andreas Sygros Hospital, Athens, Greece.

Department of Public Health Policy, School of Public Health, University of West Attica, Athens, Greece.

出版信息

Skin Appendage Disord. 2019 Nov;5(6):355-358. doi: 10.1159/000501888. Epub 2019 Aug 28.

DOI:10.1159/000501888
PMID:31799262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6883467/
Abstract

INTRODUCTION

Frontal fibrosing alopecia (FFA) is a cicatricial alopecia whose incidence has greatly increased worldwide over the last years. The main purpose of the study was to investigate the possible association of the social status of FFA patients with the prognosis of the disease.

METHODS

A total of 100 female patients with FFA, monitored at Andreas Sygros Hospital, Athens, Greece, during the last 3 years, were recruited in this observational study. The age of the women ranged from 29 to 92 years with a mean age of 61.2 years (SD = 10.3); 97% of them were Greek, with skin type II and III.

RESULTS

In total, 46% of the patients were intermediate graduates, and 42% had received tertiary education; 82% were married and 21% had 1 child. The duration of the disease ranged from 0.5 to 20 years with a mean duration of 5.2 years. In 53% of the women, the frontal hairline recession was <1 cm, in 26% it was 1-2 cm, and in 15% it was 3-4.99 cm. Overall, 55.6% of patients were professionals, 26% were technicians and associate professionals, 23% were office workers, 9% were service and sales workers, and 13% were at elementary occupations. The severity of the disease was higher in lower-educated patients, who belong to the category of unskilled or with elementary occupation.

CONCLUSIONS

Women with high educational level and social status are more likely to be diagnosed earlier, resulting in sufficient therapeutic response.

摘要

引言

额部纤维性秃发(FFA)是一种瘢痕性秃发,在过去几年中其发病率在全球范围内大幅上升。本研究的主要目的是调查FFA患者的社会地位与疾病预后之间可能存在的关联。

方法

本观察性研究招募了过去3年在希腊雅典安德烈亚斯·西格罗斯医院接受监测的100名FFA女性患者。这些女性的年龄在29岁至92岁之间,平均年龄为61.2岁(标准差 = 10.3);其中97%为希腊人,皮肤类型为II型和III型。

结果

总体而言,46%的患者为中等学历毕业生,42%接受过高等教育;82%已婚,21%育有1个孩子。疾病持续时间为0.5年至20年,平均持续时间为5.2年。53%的女性额发际线后退小于1厘米,26%为1 - 2厘米,15%为3 - 4.99厘米。总体而言,55.6%的患者为专业人员,26%为技术人员和准专业人员,23%为办公室职员,9%为服务和销售人员,13%从事基础职业。疾病严重程度在受教育程度较低、属于非技术或基础职业类别的患者中更高。

结论

教育水平和社会地位较高的女性更有可能更早被诊断出来,从而获得充分的治疗反应。